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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Smad2/3 signaling
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Smad2/3 signaling" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: Norcoclaurine; Demethyl-Coclaurine
12
12 Publications Verification
Cat. No.: HY-N2037A
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride
Category:
Plants Lindera aggregata (Sims) Kosterm. Alkaloids Phenols Polyphenols Lauraceae Disease Research Fields Isoquinoline Alkaloids Endocrinology Cancer
Target:
5
Target:
Research Areas:
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
4
4 Cited Publications
Target:
Research Areas:
NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation .
2
2 Cited Publications
Cat. No.: HY-N6985
CAS No.: 27548-93-2
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
Target:
2
2
Category:
other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
1
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-N4107
CAS No.: 10351-88-9
Category:
Phyllanthus urinaria Linn. Lignans Metabolic Disease Euphorbiaceae Phenylpropanoids Plants Disease Research Fields
Target:
Cat. No.: HY-162405
CAS No.: 2949393-27-3
Target:
Research Areas:
STAT6-IN-12 is a potent STAT6 inhibitor with an IC50 of 50 nM. STAT6-IN-12 also inhibits Smad2/3 with an IC50 of 68 nM. STAT6-IN-12 inhibits TGFβ-dependent Smad2/3 signaling pathway, IL-4-dependent STAT6 signaling pathway, and cellular inflammatory responses. STAT6-IN-12 can be used for the research of inflammation .
Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536
Target:
Research Areas:
Cat. No.: HY-171878
CAS No.: 894784-05-5
Target:
Research Areas:
BI-4659 is a TGFβRI and PDGFRα inhibitor with IC50 values of 19 nM and 99 nM, respectively. BI-4659 inhibits the kinase activities of TGFβRI and PDGFRα, blocks the downstream TGFβRI signaling pathway, and reduces the phosphorylation level of Smad2/3 without altering the expression of TGF-β1. BI-4659 is applicable to research related to pulmonary fibrosis, cancer, and renal ischemia-reperfusion injury .
Cat. No.: HY-100830A
CAS No.: 2749881-54-5
Target:
Research Areas:
NCB-0970 is the negative control of NCB-0846 (HY-100830). NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation .
Cat. No.: HY-107614G
CAS No.: 325465-93-8
Synonyms: 1-Oleoyl-sn-glycero-3-phosphate sodium (GMP); 1-Oleoyl-LPA sodium (GMP)
Synonyms: Norcoclaurine (Standard); Demethyl-Coclaurine (Standard)
Cat. No.: HY-N4107R
CAS No.: 10351-88-9
Target:
Cat. No.: HY-N0363AR
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate (Standard)
Category:
Target:
Cat. No.: HY-N2037AR
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride (Standard)
Cat. No.: HY-N2037AS1
Synonyms: Norcoclaurine-d4-1 hydrochloride; Demethyl-Coclaurine-d4-1 hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
