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Results for "

Src kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Src (134) 5-HT Receptor (2) Adrenergic Receptor (3) Akt (8) AMPK (2) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (4) Antibiotic (2) Apoptosis (35) Aurora Kinase (3) Autophagy (15) Bacterial (7) Bcl-2 Family (2) Bcr-Abl (27) Btk (5) c-Fms (1) c-Kit (10) c-Met/HGFR (3) c-Myc (2) CaMK (2) Cathepsin (1) CD44 (1) CDK (2) Chemerin Receptor (1) Collagen (1) COX (1) DNA-PK (1) Drug Derivative (1) Drug Metabolite (2) EGFR (14) Endogenous Metabolite (1) Ephrin Receptor (5) ERK (8) FAK (5) Ferroptosis (2) FGFR (15) FLT3 (4) Formyl Peptide Receptor (FPR) (1) GSK-3 (2) HIF/HIF Prolyl-Hydroxylase (1) HIV (2) IGF-1R (1) IKK (1) Insulin Receptor (1) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (5) JAK (5) JNK (4) LIM Kinase (LIMK) (1) MAP3K (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (1) MEK (2) Microtubule/Tubulin (1) Mitosis (2) MMP (3) MNK (3) mTOR (3) NF-κB (5) NO Synthase (4) NOD-like Receptor (NLR) (4) P-selectin (1) p38 MAPK (14) PANoptosis (1) PDGFR (21) Phosphodiesterase (PDE) (2) PI3K (4) Pim (2) PKA (3) PKC (6) PKD (2) Polo-like Kinase (PLK) (1) Prostaglandin Receptor (1) PROTACs (1) Pyk2 (1) Raf (5) Ras (1) Reactive Oxygen Species (ROS) (4) Reference Standards (20) RET (1) Ribosomal S6 Kinase (RSK) (2) Secretin Receptor (2) STAT (6) Stearoyl-CoA Desaturase (SCD) (2) Survivin (1) Syk (6) TAM Receptor (1) Target Protein Ligand-Linker Conjugates (1) TGF-β Receptor (2) TNF Receptor (3) TOPK (1) VEGFR (28)
By Research Areas:	Cancer (127) Cardiovascular Disease (10) Endocrinology (7) Infection (13) Inflammation/Immunology (39) Metabolic Disease (5) Neurological Disease (18)
Click Chemistry:	Alkynes (1)

176

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Src SHP2 SHP1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12047

Ponatinib 45+ Cited Publications AP24534	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and *Src*, respectively .

HY-10234

Saracatinib 35+ Cited Publications AZD0530	Src Autophagy	Cancer
Saracatinib (AZD0530) is a potent *Src* family inhibitor with IC₅₀s of 2.7 to 11 nM for *c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases* .

HY-13805

PP2 Maximum Cited Publications 62 Publications Verification AGL 1879	Src	Cancer
PP2 is a reversible and ATP-competitive *Src* family kinases inhibitor with IC₅₀s of 4 and 5 nM for Lck and Fyn, respectively.

HY-10158

Bosutinib 20+ Cited Publications SKI-606	Src Bcr-Abl Autophagy	Cancer
Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC₅₀ of 1.2 nM and 1 nM, respectively .

HY-101053

Src Inhibitor 1 15+ Cited Publications Src kinase Inhibitor 1; Src-l1	Src	Cancer
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site *Src* tyrosine kinase inhibitor with IC₅₀ values of 44 nM for Src and 88nM for Lck.

HY-108766

Ponatinib hydrochloride 45+ Cited Publications AP24534 hydrochloride	Bcr-Abl FGFR PDGFR VEGFR Src Autophagy	Infection Cancer
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and *Src*, respectively .

HY-12299

WH-4-023 5 Publications Verification Dual LCK/Src inhibitor	Src	Cancer
WH-4-023 is a potent and selective dual *Lck/Src* inhibitor with IC₅₀ of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

HY-13804

PP1 10+ Cited Publications AGL 1872; EI 275	Src Apoptosis	Cancer
PP1 is a potent, and *Src* family-selective tyrosine kinase inhibitor with IC₅₀ of 5 and 6 nM for Lck and Fyn, respectively.

HY-B0789

SU6656 20+ Cited Publications	Src FAK Akt	Cancer
SU6656 is a **Src family kinases inhibitor with IC₅₀*s of 280, 20, 130, 170 nM for Src*, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

HY-10395

PD173955 1 Publications Verification	Bcr-Abl Src	Cancer
PD173955 is an orally active inhibitor of *Src* (IC₅₀= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity .

HY-112096

eCF506 5+ Cited Publications NXP900	Src	Cancer
eCF506 (NXP900) is a highly potent and orally active *YES1/SRC* kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .

HY-18832

AWL-II-38.3	Ephrin Receptor	Cancer
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf .

HY-15764A

A 419259 trihydrochloride 5+ Cited Publications RK 20449 trihydrochloride	Src Apoptosis	Cancer
A 419259 trihydrochloride is a **Src family kinases inhibitor with IC₅₀s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn**, respectively .

HY-13942

1-NM-PP1 5+ Cited Publications PP1 Analog II	Src	Cancer
1-NM-PP1, a cell-permeable PP1 analog, is a potent **Src family kinases inhibitor with IC₅₀*s of 4.3 nM and 3.2 nM for v-Src*-as1 and c-Fyn-as1, respectively .

HY-10372

PP121 4 Publications Verification	mTOR PDGFR VEGFR Src Apoptosis	Cancer
PP121 is a multi-targeted kinase inhibitor with IC₅₀s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, *Src, PDGFR*, respectively.

HY-13561

AZM475271 M475271	Src Apoptosis	Cancer
AZM475271 (M475271) is an orally active and selective **Src kinase** inhibitor. AZM475271 inhibits phosphorylation of c-Src kinase, Lck, c-yes (IC₅₀s = 0.01, 0.03, 0.08 μM, respectively). AZM475271 induces apoptosis. AZM475271 reduces tumor cell proliferation and migration in vitro and in vivo, and reduces microvessel density (MVD). AZM475271 inhibits tumor growth and metastasis. AZM475271 sensitizes tumor cells to the cytotoxic effects of Gemcitabine (HY-17026) .

HY-10520

CGP 57380 3 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

HY-10158A

Bosutinib hydrate 20+ Cited Publications SKI-606 hydrate	Src Bcr-Abl	Cancer
Bosutinib hydrate is an oraly activel **Src/Abl tyrosine kinase inhibito with IC₅₀** of 1.2 nM and 1 nM, respectively .

HY-W062835

CGP77675	Src	Cancer
CGP77675 is an orally active and potent inhibitor of *Src* family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC₅₀s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity .

HY-13941

1-Naphthyl PP1 3 Publications Verification 1-NA-PP 1	Src PKD	Neurological Disease Inflammation/Immunology Cancer
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of *src* family kinases and *Protein Kinase* D*. 1-Naphthyl PP1 inhibits v-Src* and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively .

HY-135299

CH6953755 5 Publications Verification	Src	Cancer
CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC₅₀ of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo .

HY-11011

A-770041 5+ Cited Publications	Src	Inflammation/Immunology
A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC₅₀ value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection .

HY-118144

PD166326	Src Bcr-Abl p38 MAPK	Cancer
PD166326 is an orally active tyrosine kinase inhibitor with a IC₅₀ of 8 nM against abl tyrosine kinase and a IC₅₀ of 6 nM against *src* tyrosine kinase. PD166326 blocks Bcr/Abl kinase activity. PD166326 inhibits Bcr/Abl-dependent proliferation and cell cycle progression. PD166326 reduces peripheral blood granulocytosis, alleviates splenomegaly and prolongs survival in a mouse model of chronic myeloid leukemia. PD166326 can be used in research related to chronic myeloid leukemia .

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and *Src* kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-13941B

1-Naphthyl PP1 hydrochloride 3 Publications Verification 1-NA-PP 1 hydrochloride	Src PKD	Neurological Disease Inflammation/Immunology Cancer
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of *src* family kinases and *Protein Kinase* D*. 1-Naphthyl PP1 hydrochloride inhibits v-Src* and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively .

HY-10181S

Dasatinib-d8 1 Publications Verification BMS-354825-d₈	Bcr-Abl Src Apoptosis Autophagy	Cancer
Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-107447

N-Deshydroxyethyl Dasatinib N-Deshydroxyethyl BMS-354825	Drug Metabolite Target Protein Ligand-Linker Conjugates Bcr-Abl	Inflammation/Immunology Cancer
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research .

HY-107779

BI-882370	Raf	Cancer
BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAF ^V600E-mutant, the WT BRAF and CRAF kinases with IC₅₀s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases .

HY-15749

XL228 4 Publications Verification	Aurora Kinase Bcr-Abl IGF-1R Src	Endocrinology Cancer
XL228 is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, *Src* and Lyn, respectively.

HY-N2521

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-N6596

7-Hydroxy-4H-chromen-4-one 2 Publications Verification 7-Hydroxychromone	Src	Cancer
7-Hydroxychromone is a **Src kinase inhibitor with an IC₅₀** of <300 μM.

HY-10185

TG 100572 Hydrochloride 3 Publications Verification	Src VEGFR FGFR PDGFR	Inflammation/Immunology
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀*s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src*, Yes, respectively.

HY-108486

Herbimycin A	Bacterial Antibiotic	Infection
Herbimycin A, an ansamycin antibiotic, acts as a **Src family kinase** inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-12047S

Ponatinib-d8 AP24534-d₈	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib-d₈ (AP24534-d₈) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-163144

DAS-5-oCRBN	PROTACs Src	Cancer
DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines .

HY-10186

TG 100801 1 Publications Verification	VEGFR FGFR PDGFR Src	Cancer
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes**, respectively.

HY-10234A

Saracatinib difumarate 35+ Cited Publications AZD0530 difumarate	Src	Cancer
Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .

HY-10184

TG 100572	Src VEGFR PDGFR FGFR	Cancer
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and **Src kinases; has IC₅₀*s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src*, Yes, respectively.

HY-127002

Squarunkin A	Src	Cancer
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC₅₀=10 nM). Squarunkin A interferes with the activation of **Src kinase** in cells .

HY-136895

AZ12672857	Prostaglandin Receptor	Cancer
AZ12672857 is an orally active inhibitor of EphB4 (IC₅₀=1.3 nM) and **Src kinases*. AZ12672857 shows good inhibition of proliferation of c-Src* transfected 3T3 cells (IC₅₀=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC₅₀=9 nM) .

HY-N7160

2-Hydroxy-3-methylanthraquinone	Src Apoptosis	Cancer
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-120595

JNJ-49095397 RV568	p38 MAPK Src	Inflammation/Immunology
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits **SRC kinase** family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma .

HY-137918

TGF-βRI inhibitor 3	Src TGF-β Receptor Anaplastic lymphoma kinase (ALK)	Others
TGF-βRI inhibitor 3 (Compound 9ac) is a selective TGF-β inhibitor. TGF-βRI inhibitor 3 can effectively inhibit the TGF-β signaling pathway. TGF-βRI inhibitor 3 has IC₅₀ values of 13 μM and 0.63 μM for *c-Src* kinase and ALK5 kinase, respectively .

HY-P1784A

Secretin, canine TFA	Secretin Receptor	Endocrinology
ecretin, canine TFA is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine TFA can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .

HY-176461

Pro-Dasatinib	Src Bcr-Abl	Cancer
Pro-Dasatinib (compound 2j), an amino acid analog of Dasatinib (HY-10181), is a potent *Src/Abl* kinase inhibitor. Pro-Dasatinib has antiproliferative activity against K652 leukemia cancer cells with an IC₅₀ of 0.21 nM.

HY-108766R

Ponatinib hydrochloride (Standard) AP24534 hydrochloride (Standard)	Bcr-Abl FGFR PDGFR VEGFR Src Autophagy Reference Standards	Infection Cancer
Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride). This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .

HY-175809

SRT6	CD44 Src EGFR MAPKAPK2 (MK2)	Cancer
SRT6 is a CD44 inhibitor. SRT6 exerts antiproliferative activity in CD44 ⁺ breast cancer and lung cancer cells. SRT6 inhibits CD44-associated *SRC* kinase, as well as EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2. SRT6 can be used for the research of breast cancer and lung cancer .

HY-W013857

Lavendustin C	CaMK EGFR Src	Cancer
Lavendustin C is a potent *Ca ²⁺ calmodulin-dependent kinase* II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR*-associated tyrosine kinase* (IC₅₀=0.012 µM) and pp60 ^c-src(+) kinase (IC₅₀=0.5 µM) .

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for **src-tyrosine-specific protein kinase** .

HY-P3773

p60c-src substrate II	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

Cat. No.	Product Name	Type

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates **Src kinase, Akt, induces p-AMPK and nitric oxide synthesis**. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and *Src* kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-107024

Osteogenic Growth Peptide (10-14) OGP(10-14); Historphin	Src	Others
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a *Src* inhibitor .

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P1784A

Secretin, canine TFA	Secretin Receptor	Endocrinology
ecretin, canine TFA is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine TFA can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for **src-tyrosine-specific protein kinase** .

HY-P3773

p60c-src substrate II	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-P3743

p60c-src Substrate	Src Peptides	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P2548

pp60 (v-SRC) Autophosphorylation Site, Phosphorylated	EGFR	Others
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .

HY-P10527

CSK substrate	Src	Others
CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

HY-P2547A

*Tyrosine Kinase* Peptide 1 acetate**	Src	Others
Tyrosine Kinase Peptide 1 (acetate) is a control substrate peptide for c-Src assay .

HY-P2547

*Tyrosine Kinase* Peptide 1**	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-P2372

P60v-src(137-157)	Src	Others
P60v-src(137-157) is a synthetic peptide that inhibits the tyrosine kinase activity of p60 ^v-src (IC₅₀: 7.5 μM) .

HY-P10372

pFYN peptide	Src	Cancer
pFYN peptide is a biotin-labled phosphorylated peptide substrate derived from FYN (a Src family kinase) .

HY-P1784

Secretin, canine	Secretin Receptor	Endocrinology
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

HY-P11450

MGCVQCKDKEA	Peptides	Others
MGCVQCKDKEA is an 11-residue membrane-anchoring motif derived from the Src kinase Fyn. MGCVQCKDKEA can promote the cell surface expression of TMC1/2 proteins. MGCVQCKDKEA can be used in the research of inner ear mechanical conduction channel-related diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991664

AG01	Src Akt ERK TAM Receptor c-Met/HGFR MMP HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
AG01 is a monoclonal antibody against progranulin (GP88). AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases *p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF*. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16558

Butein Maximum Cited Publications 6 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Chalcones Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N0031

Plantamajoside 2 Publications Verification	Plantaginaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB PI3K Akt Apoptosis Autophagy p38 MAPK Src
Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects .

HY-N0701

(-)-Asarinin 1 Publications Verification	Asarum sieboldii Miq. Classification of Application Fields Lignans Phenylpropanoids Plants Aristolochiaceae Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a *Src* family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .

HY-N0442

5-O-Methylvisammioside 4'-O-β-D-Glucosyl-5-O-methylvisamminol	Structural Classification Ophryosporus axilliflorus Hieron. Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Umbelliferae Plants Disease Research Fields Source Classification	NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting *Src* kinase and the NF-κB pathway .

HY-N2521

Tetramethylcurcumin FLLL31	other families Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	STAT Apoptosis
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-N6596

7-Hydroxy-4H-chromen-4-one 2 Publications Verification 7-Hydroxychromone	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Celastraceae Phenols Tripterygium wilfordii Hook. f. Plants Disease Research Fields Source Classification Cancer	Src
7-Hydroxychromone is a **Src kinase inhibitor with an IC₅₀** of <300 μM.

HY-108486

Herbimycin A	Infection Quinones Microorganisms Classification of Application Fields Benzene Quinones Disease Research Fields Source Classification	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a **Src family kinase** inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N4201

β-Hydroxyisovalerylshikonin	Quinones Classification of Application Fields Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer Source Classification	EGFR Src
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of *protein tyrosine kinases* (PTK), with IC₅₀*s of 0.7μM and 1μM for EGFR and v-Src* receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Anthraquinones Rubiaceae Plants Source Classification Hedyotis diffusa Willd.	Src Apoptosis
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Natural Products Pinaceae Plants Source Classification	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-N14271

Hibarimicin B Angelmicin B	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin B (Angelmicin B) is a tyrosine kinase inhibitor. It selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. It also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14273

Hibarimicin C	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin C is a tyrosine kinase inhibitor. Hibarimicin C selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin C also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14689

Hibarimicin D	Natural Products Microorganisms Source Classification	Src
Hibarimicin D is a tyrosine kinase inhibitor. Hibarimicin D selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin D also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N14267

Hibarimicin A	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Src Bacterial
Hibarimicin A is a tyrosine kinase inhibitor found in Microbispora rosea subsp. hibaria. Hibarimicin A selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin A also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .

HY-N15076

Herbimycin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Src Antibiotic Bacterial
Herbimycin B is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Herbimycin B has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells .

HY-N0701R

(-)-Asarinin (Standard)	Asarum sieboldii Miq. Structural Classification Lignans Phenylpropanoids Plants Aristolochiaceae Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin (HY-N0701). This product is intended for research and analytical applications. (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a *Src* family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.

HY-N0031R

Plantamajoside (Standard)	Plantaginaceae Structural Classification Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants Source Classification	Reference Standards NF-κB PI3K Apoptosis Autophagy p38 MAPK Src
Plantamajoside (Standard) is the analytical standard of Plantamajoside. This product is intended for use in research and analytical applications. Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects .

HY-N0442R

5-O-Methylvisammioside (Standard) 4'-O-β-D-Glucosyl-5-O-methylvisamminol (Standard)	Structural Classification Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Umbelliferae Plants Source Classification	Reference Standards p38 MAPK Reactive Oxygen Species (ROS) TNF Receptor MEK ERK VEGFR Src Amyloid-β Anaplastic lymphoma kinase (ALK) NF-κB NOD-like Receptor (NLR) JNK Ferroptosis
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) (Standard) is the analytical standard of 5-O-Methylvisammioside. This product is intended for research and analytical applications. 5-O-Methylvisammioside is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting *Src* kinase and the NF-κB pathway.

Species:	Human (9) Mouse (4)
Tag:	His (8) Strep (1) Tag Free (3) Avi (1) GST (6) Flag (2)
Source:	sf9 insect cells (2) Sf9 insect cells (2) Sf9 insect cells (8) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73422

	Src Protein, Human (Active, sf9, His-GST) Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; Src1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P73423

	Src Protein, Mouse (Active, sf9, His-GST) Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; Src1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702724

	Src Protein, Human (Active, sf9, His, Flag) Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; Src1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells, with His, Flag labeled tag.

HY-P701321

	Src Protein, Human (Active, His) 1 Publications Verification Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src (p60-Src); Src1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag.

HY-P705885

	Src Protein, Human (Active, sf9) Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src (p60-Src); Src1	Human	sf9 insect cells

HY-P705884

	Src Protein, Human (Active, T341M, sf9, His-StrepII) Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src (p60-Src); Src1	Human	sf9 insect cells

HY-P75322

	CSK Protein, Mouse (sf9) Tyrosine-protein kinase CSK; C-Src kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with tag free.

HY-P72956

	CSK Protein, Human (Active, sf9, GST) Tyrosine-protein kinase CSK; C-Src kinase; CSK	Human	Sf9 insect cells
	CSK is a non-receptor tyrosine protein kinase that critically regulates cell growth, differentiation, migration and immune responses by phosphorylating tyrosine residues in the C-terminal tail of Src family kinases (SFK). This induces an inactive conformation through intramolecular interactions with the SH2 domain of SFK. CSK Protein, Human (Active, sf9, GST) is the recombinant human-derived CSK protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P72957

	CSK Protein, Mouse (Active, sf9, His-GST) Tyrosine-protein kinase CSK; C-Src kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72856

	Brk Protein, Mouse (Active, sf9, His-GST) Protein-tyrosine kinase 6; Src-related intestinal kinase; Ptk6; Sik	Mouse	Sf9 insect cells
	Brk protein is a non-receptor tyrosine protein kinase that regulates signaling pathways critical for epithelial differentiation and tumor growth.Its context-dependent functions involve phosphorylating substrates such as RNA-binding proteins, transcription factors, and signaling molecules.Brk Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Brk protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75470

	Brk/PTK6 Protein, Human (sf9, GST) Protein-tyrosine kinase 6; Src-related intestinal kinase; Ptk6; Sik	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk/PTK6 Protein, Human (sf9, GST) is the recombinant human-derived Brk protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P702727

	FYN Protein, Human (Active, Biotinylated, sf9, His, Flag, Avi) FYN; FYN oncogene related to Src, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; Src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; Src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regulator; p59-FYN	Human	Sf9 insect cells
	FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) is the recombinant human-derived FYN, expressed by Sf9 insect cells , with Avi, His, Flag labeled tag.

HY-P705567

	Lck Protein, Human (sf9) Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase (LSK); Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	Human	Sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-10181S

Dasatinib-d8 1 Publications Verification
Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-12047S

Ponatinib-d8
Ponatinib-d₈ (AP24534-d₈) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base . Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-10230S

Midostaurin-d5
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-112096S

eCF506-d5

eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .

HY-10158S1

Bosutinib-13C,d3
Bosutinib- ¹³C,d₃ (SKI-606- ¹³C,d₃) is ¹³C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC₅₀ of 1.2 nM and 1 nM, respectively .

HY-10234S

Saracatinib-d3
Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the *Src* kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-112852S

TL02-59-d5
TL02-59-d₅ is the deuterium labeled TL02-59 (HY-112852). TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an ICC₅₀ of 0.03 nM. TL02-59 inhibits Lyn and Hck with ICC₅₀s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth.

Host:	Mouse (8) Rabbit (10)
Reactivity:	Human (16) Mouse (8) Rat (10) Monkey (2)
Application:	IHC-P (6) ICC/IF (11) IF-Tissue (1) IP (6) IHC-F (1) WB (18) FC (3) ELISA (6)
Isotype:	IgG (7) IgG1 (2) IgG/Kappa (3)
Conjugation:	Non-conjugated (18) Biotin (1)
Clonality:	Polyclonal (1) Monoclonal (14) Recombinant (4)
Modification:	Phosphorylated (2) Unmodified (13)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85546

	CSK Antibody (YA5238) C Src; C Src kinase; C Src Tyrosine kinase; C-Src kinase; c-Src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE kinase; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL; Proto oncogene tyrosine protein kinase; Tyrosine protein kinase CSK; Tyrosine protein kinase CSK; Tyrosine-protein kinase CSK; zgc:154049.	WB, ICC/IF	Human, Rat
	CSK Antibody (YA5238) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CSK.

HY-P86318

	Src Antibody (YA6010) Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src; p60-Src;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Src Antibody (YA6010) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Src.

HY-P82911

	Phospho-Src (Tyr530) Antibody (YA2656) Src; Src1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src; p60-Src	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src (Tyr530).

HY-P86105

	Phospho-Src Family(Tyr416) Antibody (YA5797) Src; Src1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src; p60-Src; ASV;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Src Family(Tyr416) Antibody (YA5797) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src Family(Tyr416).

HY-P82911A

	Phospho-Src (Tyr530) Antibody (YA2656)(PBS only) Src; Src1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-Src; p60-Src	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Src (Tyr530).

HY-P82997

	CSK Antibody (YA2742) CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL	WB, IHC-P	Human, Mouse, Rat
	CSK Antibody (YA2742) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CSK.

HY-P85111

	CSK Antibody (YA4803) CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	CSK Antibody (YA4803) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CSK.

HY-P85545

	Fyn Antibody (YA5237) C syn protooncogene; Fyn; FYN oncogene related to Src FGR YES; FYN_HUMAN; MGC45350; OKT3 induced calcium influx regulator; P59 FYN; p59-Fyn; Protein tyrosine kinase fyn; Proto oncogene tyrosine protein kinase fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Protooncogene Syn; SLK; Src like kinase; Src yes related novel gene; Src-like kinase; Src/yes related novel; Src/yes related novel gene; SYN; Tyrosine kinase p59fyn T; Tyrosine kinase p59fyn; T; Tyrosine-protein kinase Fyn.	WB, ICC/IF	Human, Monkey, Rat, Mouse
	Fyn Antibody (YA5237) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fyn.

HY-P83492

	MLK3 Antibody (YA3237) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MLK3.

HY-P83492A

	MLK3 Antibody (YA3237)(PBS only) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MLK3.

HY-P80681

	Fyn Antibody FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn	WB	Human, Mouse, Rat
	Fyn Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Fyn.

HY-P85176

	Fyn Antibody (YA4868) FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Fyn Antibody (YA4868) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fyn.

HY-P80743

	Lck Antibody (YA712) LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

HY-P86477

	Lck Antibody (YA6169) LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lck Antibody (YA6169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lck.

HY-P85255

	Lck Antibody (YA4947) LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human
	Lck Antibody (YA4947) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P80743A

	Lck Antibody (YA712)(PBS only) LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

HY-P85555

	Lck Antibody (YA5247) LCK; Lck p56; LCK_HUMAN; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte cell-specific protein-tyrosine kinase; Lymphocyte Specific Protein Tyrosine kinase; Membrane associated protein tyrosine kinase; Oncogene lck; P56 LCK; p56; LSTRA; protein tyrosine kinase; p56-LCK; p56lck; pp58 lck; pp58lck; Protein YT16; Proto oncogene tyrosine protein kinase LCK; Proto-oncogene Lck; Protooncogene tyrosine protein kinase LCK; T cell specific protein tyrosine kinase; T cell-specific protein-tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56lck; Tyrosine-protein kinase Lck; YT 16; YT16.	WB	Human
	Lck Antibody (YA5247) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P85100

	FGR Antibody (YA4792) FGR; Src2; Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr; oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	FGR Antibody (YA4792) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FGR.

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HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

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