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U-87 MG

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Payload (1) Adenosine Receptor (1) Adrenergic Receptor (3) Akt (2) Apoptosis (36) Aryl Hydrocarbon Receptor (1) Autophagy (18) Bacterial (3) Bcl-2 Family (2) c-Met/HGFR (1) Cadherin (1) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Casein Kinase (1) Caspase (2) Choline Kinase (1) Cholinesterase (ChE) (1) CXCR (1) Deubiquitinase (1) DNA/RNA Synthesis (2) Dopamine Receptor (5) Drug Intermediate (1) Early 2 Factor (E2F) (1) EGFR (1) Endogenous Metabolite (7) Ephrin Receptor (2) Epigenetic Reader Domain (1) ERK (1) FAK (3) FAP (1) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) GABA Receptor (2) GnRH Receptor (1) HDAC (1) Hedgehog (1) Histamine Receptor (3) Histone Demethylase (1) HSP (2) Hsp-targeting Chimeras (2) IAP (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isocitrate Dehydrogenase (IDH) (4) Isotope-Labeled Compounds (9) Leukotriene Receptor (2) LXR (1) LYTACs (1) Microtubule/Tubulin (10) Mitochondrial Metabolism (1) MMP (1) Monoamine Oxidase (1) NF-κB (2) OLIG2 (1) Oxysterol-binding Protein-related Protein (ORP) (1) PARP (2) PD-1/PD-L1 (1) PDGFR (1) Peptide-Drug Conjugates (PDCs) (1) PERK (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Phospholipase (2) PI3K (4) PROTACs (5) Pyruvate Kinase (1) Ras (1) Reactive Oxygen Species (ROS) (10) Reference Standards (6) RSV (2) Serotonin Transporter (9) Sigma Receptor (1) Sirtuin (1) STAT (2) Survivin (1) Topoisomerase (3) Trk Receptor (1) TRP Channel (1) VDAC (1) VEGFR (5)
By Research Areas:	Cancer (90) Cardiovascular Disease (1) Endocrinology (3) Infection (4) Inflammation/Immunology (18) Metabolic Disease (1) Neurological Disease (21)
Click Chemistry:	Alkynes (1)

101

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12033

2-Methoxyestradiol Maximum Cited Publications 33 Publications Verification 2-ME2; NSC-659853	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-B1490

Imipramine hydrochloride 5+ Cited Publications	Serotonin Transporter Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-N0662

Amentoflavone 15+ Cited Publications Didemethyl-ginkgetin	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B1490A

Imipramine 5+ Cited Publications	Serotonin Transporter Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-A0077

Perphenazine 3 Publications Verification	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

HY-111449

BAY-218 2 Publications Verification AHR antagonist 1	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC₅₀ of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses .

HY-14550

TP-10 2 Publications Verification	Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease
TP-10 is a selective PDE10A inhibitor with an IC₅₀ value of 0.8 nM. TP-10 shows an antioxidant activity with IC₅₀s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-12833

AMZ30 1 Publications Verification	Phosphatase Akt ERK	Others
AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC₅₀s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma .

HY-108693

β-Tocotrienol	Leukotriene Receptor Apoptosis	Inflammation/Immunology
β-Tocotrienol is an isomer of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol. β-Tocotrienol can be found in the tocotrienol-rich fraction (TRF) of palm oil, which possesses anti-carcinogenic effects in vitro on human colon carcinoma and prostate cancer cells. β-Tocotrienol inhibits the growth of A549 (GI₅₀ = 1.38 μM) and U87MG (GI₅₀ = 2.53 μM) cells. β-Tocotrienol also induces apoptosis in cancer cells. β-Tocotrienol can inhibit PD-L1 expression and mitigates PD-L1-mediated immune suppression in vitro and in vivo .

HY-153627

GK13S	Deubiquitinase	Cancer
GK13S is a deubiquitinase UCHL1 ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16532

Zoptarelin doxorubicin AEZS-108; AN-152	Peptide-Drug Conjugates (PDCs) GnRH Receptor	Cancer
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .

HY-116273

ML299	Phospholipase	Cancer
ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC₅₀ values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells .

HY-12033S2

2-Methoxyestradiol-d5 2-ME2-d₅; NSC-659853-d₅	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-168708

AH2-14c	Histone Demethylase Apoptosis	Cancer
AH2-14c is an inhibitor for DNA demethylase ALKBH2. AH2-14c inhibits the cell viability (IC₅₀ is 4.56 µM) and migration of GBM U87. AH2-14c regulates the expression of apoptosis-related genes, and induces apoptosis in GBM U87 cell .

HY-155439

FAK-IN-14	FAK	Cancer
FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC₅₀ value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis and arrest the cell at the G2/M phase .

HY-149530

EGFR-IN-86	EGFR Apoptosis	Cancer
EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC₅₀: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .

HY-173066

NU227326	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Cancer
NU227326 is a blood-brain barrier penetrant IDO1 PROTAC degrader, with a DC₅₀ of 4.5 nM in HiBiT degradation assays. NU227326 degrades IDO1 in U87 and GBM43 cells, with DC₅₀ values of 7.1 nM and 11.8 nM, respectively (WB assays). NU227326 is applicable to research related to glioblastoma, prostate cancer, triple-negative breast cancer, pancreatic cancer, and ovarian cancer .

HY-N3001

Isolinderalactone 1 Publications Verification	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase	Neurological Disease Inflammation/Immunology Cancer
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-15398C

3-epi-Vitamin D3 Epicholecalciferol	Hedgehog	Cancer
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC₅₀ of 39.2 μM measured in U87MG cells .

HY-106892

BW 348U87 348U87	DNA/RNA Synthesis	Infection
BW 348U87 is an inhibitor for ribonucleotide reductase, which exhibits synergistic effect with Acyclovir (HY-17422), potentiate the antiviral activity of Acyclovir against herpes simplex virus (HSV) in athymic nude mouse model .

HY-168969

AA-BR-157	PROTACs	Neurological Disease Cancer
AA-BR-157 is a metallothionein 2A (MT2A) PROTAC degrader, DC₅₀ is 200 nM (MT2A overexpressed in MDA-MB-231 cells). AA-BR-157 increases intracellular zinc levels, downregulates DIAPH3, disrupts cytoskeleton remodeling, and reduces the migration and invasion abilities of cancer cells. AA-BR-157 can be used for research on triple-negative breast cancer and glioblastoma .

HY-150401

Exatecan-amide-cyclopropanol	ADC Payload Topoisomerase	Cancer
Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC₅₀ values of 0.12 and 0.23 nM, respectively .

HY-B1490R

Imipramine hydrochloride (Standard)	Reference Standards Serotonin Transporter Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Imipramine (hydrochloride) (Standard) is the analytical standard of Imipramine (hydrochloride). This product is intended for research and analytical applications. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-136479

F0911-7667	Sirtuin	Cancer
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments .

HY-116165

ML-298	Phospholipase	Cancer
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells .

HY-13768S1

Topotecan-d6	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis .

HY-156349

Sec61-IN-4	Apoptosis	Others
Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC₅₀: 0.04 nM in U87-MG cells) .

HY-175213

Mutant IDH1-IN-7	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-7 is a highly selective Isocitrate Dehydrogenase 1 (IDH1) R132H (IC₅₀ = 0.26 μM, K_d = 2.1 μM)/R132C (IC₅₀ = 1.1 μM) inhibitor. Mutant IDH1-IN-7 has no inhibitory effect on wild-type IDH1, IDH2-wt, and IDH2 R140Q. Mutant IDH1-IN-7 inhibits 2-Hydroxyglutarate (2-HG) production in U87-MG R132H cells (EC₅₀ = 0.55 μM). Mutant IDH1-IN-7 exhibits moderate antiproliferative effects on U87-MG R132H and HT-1080 cells .

HY-175291

Cystatin B agonist 1	MMP Cadherin	Cancer
Cystatin B agonist 1 is an orally active MMP-2/9 inhibitor. Cystatin B agonist 1 exhibits inhibitory effects with IC₅₀ values of 3.95 and 3.43 μM against U87 and T98G cells, respectively. Cystatin B agonist 1 induces the cell-cycle arrest at S phase, inhibits angiogenesis, and suppresses migration and invasion of MG cells. Cystatin B agonist 1 inhibits tumor growth in U87 MG xenograft model. Cystatin B agonist 1 can be used for the study of malignant glioma (MG) .

HY-123410

KM-233	Cannabinoid Receptor	Cancer
KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research .

HY-129094

ICT5040	CXCR	Cancer
ICT5040 is a small molecule CXCR4 antagonist (IC₅₀=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells .

HY-155684

SA-PA	PROTACs VEGFR PDGFR Ephrin Receptor	Cancer
SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .

HY-19130

BW-534U87	Adenosine Receptor	Neurological Disease
BW-534U87 is an orally active adenosine A1 receptor agonist and competitive adenosine deaminase (ADA) inhibitor (K_i=7 μM). BW-534U87 elevates brain adenosine levels and suppresses epileptiform activity. BW-534U87 demonstrate anticonvulsant efficacy in animal seizure models. BW-534U87 is promising for research of epilepsy and adenosine-related neuropsychiatric disorders .

HY-175530

OLIG2-IN-1	OLIG2	Cancer
OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC₅₀ value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC₅₀ values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme .

HY-12033S1

2-Methoxyestradiol-13C6 2-ME2-¹³C₆; NSC-659853-¹³C₆	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S

2-Methoxyestradiol-13C,d3	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-131065

MET kinase-IN-2	c-Met/HGFR	Cancer
MET kinase-IN-2 is a potent, selective, orally bioavailable MET kinase inhibitor with an IC₅₀ of 7.4 nM. MET kinase-IN-2 has antitumor activity .

HY-B1490AS

Imipramine-d6	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease Inflammation/Immunology Cancer
Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490S1

Imipramine-d3 hydrochloride	Isotope-Labeled Compounds Serotonin Transporter Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490AR

Imipramine (Standard)	Serotonin Transporter Autophagy Apoptosis Reference Standards	Neurological Disease Inflammation/Immunology Cancer
Imipramine (Standard) is the analytical standard of Imipramine. This product is intended for research and analytical applications. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-114459

Mutant IDH1-IN-4	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC₅₀ values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells .

HY-A0077A

Perphenazine dihydrochloride	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation .

HY-168279

VEGF-IN-1	VEGFR	Cancer
VEGF-IN-1 (compound 6) can reduce the release of VEGF in U87-MG cells and inhibit angiogenesis in vitro. VEGF-IN-1 can inhibit cell proliferation by inducing autophagy in tumor cells, with an IC₅₀ value of 28.35 μM for U87-MG cells .

HY-146275

LXRβ agonist-3	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-178034

PROTAC OSBP Degrader-1	PROTACs Oxysterol-binding Protein-related Protein (ORP)	Cancer
PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC₅₀ of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells . Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker

HY-172159

FF2039	HDAC Apoptosis	Cancer
FF2039 (compound 1j) is a specific HDAC1, HDAC6, and HDAC isoforms of class I, IIa and IIb PROTAC degrader. FF2039 demonstrates s significant antiproliferative activity against both hematological and solid cancer cell lines, driven by cell cycle arrest and Apoptosis induction. FF2039 inhibits HDAC isoform of HDAC1, HDAC2, HDAC4 and HDAC6 with IC₅₀s of 1.03, 2.15, 12.4 and 0.053 μM, respectively. FF2039 shows antiproliferative activity against different tumor entities of MM.1S, MDA-MB-231 and U-87MG with EC₅₀s of 2.8, 28 and 30 μM, respectively. (Pink: PRMT5 ligand (HY-168864); Blue: E3 ligase ligand HY-W957284); Black: linker (HY-W881439); E3+linker (HY-172185 )) .

Cat. No.	Product Name	Target	Research Area

HY-16532

Zoptarelin doxorubicin AEZS-108; AN-152	Peptide-Drug Conjugates (PDCs) GnRH Receptor	Cancer
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .

HY-P11029

CES	Peptides	Cancer
CES (CESPLLSEC) is a homing peptide targeting Synaptosomal associated protein 25 (SNAP25). CES specifically homes in intracranial U87MG and the WT-glioblastoma (GBM) model. CES can be used as a targeting peptide for drug delivery for cancers research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12033

2-Methoxyestradiol Maximum Cited Publications 33 Publications Verification 2-ME2; NSC-659853	Monophenols Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N0662

Amentoflavone 15+ Cited Publications Didemethyl-ginkgetin	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-N3001

Isolinderalactone 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N12834

Ecdysoside B	Apocynaceae Structural Classification Plants Urceola rosea (Hook. & Arn.) D. J. Middleton Steroids Source Classification	Others
Ecdysoside B (compound 6b) is a pregnanoside compound isolated from the plant Ecdysanthera rosea. Ecdysoside B and its derivatives and isomers shows anticancer, immunosuppressive and anti-inflammatory activities. Ecdysoside B shows cytotoxicity to a variety of human tumor cell lines, including PANC-1 (human pancreatic cancer cells), A375 (human melanoma cells) and U87 (brain glioma U87 cells). Ecdysoside B can be used for research in the areas of cancer, immunomodulation and anti-inflammato .

HY-N12887

Mycothiazole	Natural Products Marine natural products Sponge Source Classification	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-12033R

2-Methoxyestradiol (Standard) 2-ME2 (Standard); NSC-659853 (Standard)	Structural Classification Monophenols Disease markers Phenols Endocrine diseases Endogenous metabolite Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite Reference Standards
2-Methoxyestradiol (Standard) is the analytical standard of 2-Methoxyestradiol. This product is intended for research and analytical applications. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N12135

15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide	Senegalia pennata (L.) Maslin Terpenoids Labiatae Diterpenoids Plants Source Classification	Others
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC₅₀s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively .

Cat. No.	Product Name	Chemical Structure

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-B1490AS

Imipramine-d6

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490S1

Imipramine-d3 hydrochloride

Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-13768S

Topotecan-d5
Topotecan-d₅ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87 .

HY-B1490S

Imipramine-d4 hydrochloride

Imipramine-d₄ (hydrochloride) is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-B1490AS1

Imipramine-d4

Imipramine-d₄ is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490AS3

Imipramine-d4-1

Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

Cat. No.	Product Name		Classification

HY-153627

GK13S		Alkynes
GK13S is a deubiquitinase UCHL1 ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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