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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
UDP-glucuronosyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "UDP-glucuronosyltransferase" in MCE Product Catalog:
19
19 Publications Verification
Cat. No.: HY-N0372
CAS No.: 58749-22-7
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Flavonoids Chalcones Leguminosae Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer
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2
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Tribulus terrester Linn. Zygophyllaceae Metabolic Disease Plants Disease Research Fields Steroids
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2
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Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Disease Research Fields Cancer
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1
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Alkaloids Microorganisms Monophenols Other Alkaloids Phenols Disease Research Fields Inflammation/Immunology
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1
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Agavaceae Plants Agave sisalana Perr. ex Engelm. Disease Research Fields Inflammation/Immunology Steroids
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1
1 Cited Publications
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4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation .
Cat. No.: HY-N0859
CAS No.: 69363-14-0
Synonyms: Schizanhenol; Gomisin-K3
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Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer
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Cat. No.: HY-N11424
CAS No.: 17459-92-6
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Cat. No.: HY-176515
CAS No.: 3118400-26-0
Synonyms: Ciprofol Glucuronide
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Cipepofol glucuronide (Ciprofol Glucuronide) (M4) is a glucuronide metabolite of Ciprofol (HY-116152). Cipepofol glucuronide has no significant inhibitory activity toward P450s and UDP-glucuronosyltransferases (UGTs), and it has a lower risk of acting as a perpetrator for drug-drug interactions (DDIs). Cipepofol glucuronide can be used for anesthesia research .
Cat. No.: HY-100319
CAS No.: 162704-20-3
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UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.
Synonyms: UR-8880
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Cimicoxib (UR-8880) is an orally active, blood-brain barrier-permeable COX-2 inhibitor that also exerts targeted inhibition on CYP2D15. It has an IC50 of 66 nM against hCOX-2, an IC50 of 1.6 μM against canine CYP2D15, and an IC50 of 0.056 μM against feline CYP2D15. By inhibiting the COX-2 pathway to reduce the production of thromboxane B2 and prostaglandin E2, Cimicoxib exerts antipyretic, anti-inflammatory and analgesic effects. Cimicoxib is metabolized by CYP2D15 to form demethyl-cimicoxib, undergoes glucuronidation via UDP-glucuronosyltransferases, and exhibits biphasic elimination kinetics in beagle dogs. Cimicoxib is widely used in studies of inflammatory diseases, osteoarthritis, and perioperative pain associated with orthopedic or soft tissue surgeries .
Category:
Alkaloids Microorganisms Monophenols Other Alkaloids Phenols
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Cat. No.: HY-N0372R
CAS No.: 58749-22-7
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Cat. No.: HY-N0235R
CAS No.: 10309-37-2
Synonyms: (S)-(+)-Bakuchiol (Standard)
Cat. No.: HY-107081
CAS No.: 172940-14-6
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Berupipam hemifumarate is a selective antagonist of the dopamine D1 receptor (dopamine D1 receptor). Berupipam hemifumarate is a substrate of UDP-glucuronosyltransferase (UGT) and has a high affinity for UGT enzymes but a relatively low conversion rate. The glucuronidation rate of Berupipam hemifumarate varies among different species and genders. Berupipam hemifumarate can be used for the study of psychotic disorders .
Cat. No.: HY-124364
CAS No.: 1578153-27-1
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RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
