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Results for "

VLCFA

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160004
    PXL770

    		AMPK Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    PXL770 is an orally active, direct allosteric AMP-activated protein kinase (AMPK) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters (ABCD2/3) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH) .
    PXL770
  • HY-156679
    VK-0214

    		Thyroid Hormone Receptor Neurological Disease Cancer
    VK-0214 is an agonist of the thyroid β receptor (TRβ). By activating the expression of ABCD2, it can reduce the accumulation of very long-chain fatty acids (VLCFAs) and further alleviate glioblastoma multiforme. VK-0214 has the effect of regulating fatty acid metabolism and can be used in the research of X-linked adrenoleukodystrophy (X-ALD) .
    VK-0214
  • HY-119633
    Perfluidone

    		Herbicide Others
    Perfluidone is a selective 3-ketoacyl-CoA synthase (KCS) inhibitor with IC50s of 0.21 and 7.60 μM for CER6 (KCS6) and FAE1 (KCS18), respectively. Perfluidone significantly inhibits very-long-chain fatty acid (VLCFA) synthesis. Perfluidone has phytotoxic activity and inhibits Lemna paucicostata growth. Perfluidone can be uses as a plant growth regulator and herbicide for agriculture research .
    Perfluidone

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