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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
VR1
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "VR1" in MCE Product Catalog:
8
8 Cited Publications
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SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM). SB-366791 can be used for the research of inflammation [1] .
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5 Cited Publications
Cat. No.: HY-19960
CAS No.: 393514-24-4
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BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects [1] .
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N-Arachidonyldopamine acts as an Anandamide (HY-10863) membrane transport inhibitor, a selective CB1 cannabinoid receptor agonist, and a VR1 receptor activator. It exhibits an EC50 value of 48 nM for rat VR1 and a Ki value of 0.25 μM for CB1. N-Arachidonyldopamine exists in mammalian neural tissues. It stimulates intracellular Ca 2+ mobilization, mediates cannabinoid-like effects, and induces hypothermia, hypomotility, catalepsy, analgesia, and hyperalgesia to heat. N-Arachidonyldopamine possesses anticancer activity against breast cancer. It can be used in research related to breast cancer and heat hyperalgesia [1] .
Cat. No.: HY-P1175
CAS No.: 206350-79-0
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Cat. No.: HY-RS15121
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TRPV1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P1175A
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Cat. No.: HY-118299
CAS No.: 623166-14-3
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JYL 1511 is a partial agonist of vanilloid receptor VR1 [1].
Cat. No.: HY-130358
CAS No.: 179469-40-0
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PDDHV is a calcium absorption inducer and may achieve 45Ca 2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca 2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats [1].
Cat. No.: HY-135882
CAS No.: 616884-67-4
Cat. No.: HY-135881
CAS No.: 616884-66-3
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
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Cat. No.: HY-P3702
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Cat. No.: HY-D3097
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Lyso-VR1 is a fluorescent probe for lysosomal viscosity detection. The detection mechanism of Lyso-VR1 relies on intramolecular rotation restriction. Due to the protonation of its indole moiety in lysosomes, this probe can specifically target lysosomes, thereby localizing to this suborganelle for viscosity monitoring. Its excitation wavelength ranges from 400-500 nm, and its emission peak under excitation at 488 nm is located at ~550 nm to ~560 nm [1].
Cat. No.: HY-19960R
CAS No.: 393514-24-4
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BCTC (Standard) is the analytical standard of BCTC. This product is intended for research and analytical applications. BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects [1] .
Cat. No.: HY-P1175B
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Cat. No.: HY-183857
CAS No.: 410080-55-6
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DD-161515 is a TRPV1/VR1 inhibitor with an IC50 of 0.7 μM in rats. DD-161515 binds to an allosteric site of TRPV1 distinct from that of capsaicin, blocks channel opening, inhibits receptor-mediated calcium ion influx, reduces the excitability of peripheral sensory nerve fibers, and thereby inhibits nociception induced by heat and transmission of chemically induced pain signals. DD-161515 can be used in studies related to inflammatory pain [1] .
Cat. No.: HY-RS16501
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Trpv1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpv1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
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Cat. No.: HY-103342
CAS No.: 616884-63-0
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
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Cat. No.: HY-135880
CAS No.: 616884-64-1
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
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Cat. No.: HY-135880A
CAS No.: 616884-65-2
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
