410080-55-6
Chemical Structure
DD-161515
- CAS No.: 410080-55-6
- Formula:C29H37Cl4N5O3
- Molecular Weight:645.45
InChIKey: YZWIGOVHAHQNDZ-UHFFFAOYSA-N
SMILES: O=C(CN(CCC1=CC=C(C=C1Cl)Cl)C(CN(CCC2=CC=C(C=C2Cl)Cl)C(CNCCC3N(CCC3)C)=O)=O)N
Biological Activity: DD-161515 is a TRPV1/VR1 inhibitor with an IC50 of 0.7 μM in rats. DD-161515 binds to an allosteric site of TRPV1 distinct from that of capsaicin, blocks channel opening, inhibits receptor-mediated calcium ion influx, reduces the excitability of peripheral sensory nerve fibers, and thereby inhibits nociception induced by heat and transmission of chemically induced pain signals. DD-161515 can be used in studies related to inflammatory pain[1][2].
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DD-161515 | DD-161515 is a TRPV1/VR1 inhibitor with an IC50 of 0.7 μM in rats. DD-161515 binds to an allosteric site of TRPV1 distinct from that of capsaicin, blocks channel opening, inhibits receptor-mediated calcium ion influx, reduces the excitability of peripheral sensory nerve fibers, and thereby inhibits nociception induced by heat and transmission of chemically induced pain signals. DD-161515 can be used in studies related to inflammatory pain. | |||||||||||||||||||||
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Keywords
