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Results for "

WDR4

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162080
    METTL1-WDR4-IN-1
    1 Publications Verification

    		 DNA Methyltransferase Pyruvate Kinase Cancer
    METTL1-WDR4-IN-1 (Compound 1) is a selective competitive inhibitor of the methyltransferase complex METTL1-WDR4 (IC50 = 144 μM). METTL1-WDR4-IN-1 inhibits the m 7G methyltransferase activity of the METTL1-WDR4 complex, blocking m 7G modification of PKM mRNA, reducing PKM2 protein expression, disrupting the METTL1/PKM2/H3K9la positive feedback loop, and simultaneously inhibiting PKM2 nuclear translocation-mediated CD155 transcriptional activation. METTL1-WDR4-IN-1 can inhibit tumor cell proliferation, weaken glycolytic metabolism, reverse tumor immune evasion (restoring NK cell and CD8 + T cell function), and regulate RNA epigenetic modification and the tumor immune microenvironment. METTL1-WDR4-IN-1 can be used in immunotherapy research for cancers such as colorectal cancer, and is particularly suitable for use in combination with PKM2 inhibitors to enhance anti-tumor treatment efficacy .
    METTL1-WDR4-IN-1
  • HY-162082
    METTL1-WDR4-IN-2

    		DNA Methyltransferase Cancer
    METTL1-WDR4-IN-2, an adenosine derivative, is a selective methyltransferase Like 1 (METTL1)-WDR4 inhibitor with an IC50 of 41 μM. METTL1-WDR4-IN-2 shows selectivity against METTL3-14 (IC50 of 958 μM) and METTL16 (IC50 of 208 μM). METTL1-WDR4-IN-2 can be used for the study of cancer .
    METTL1-WDR4-IN-2
  • HY-RS15777
    WDR4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    WDR4 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    WDR4 Human Pre-designed siRNA Set A
    WDR4 Human Pre-designed siRNA Set A
  • HY-RS22359
    Wdr4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Wdr4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wdr4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Wdr4 Mouse Pre-designed siRNA Set A
    Wdr4 Mouse Pre-designed siRNA Set A
  • HY-RS28881
    Wdr4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Wdr4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Wdr4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Wdr4 Rat Pre-designed siRNA Set A
    Wdr4 Rat Pre-designed siRNA Set A
  • HY-162080A
    METTL1-WDR4-IN-1 TFA
    1 Publications Verification

    		 DNA Methyltransferase Pyruvate Kinase Cancer
    METTL1-WDR4-IN-1 (Compound 1) TFA is a selective competitive inhibitor of the methyltransferase complex METTL1-WDR4 (IC50=144 μM). METTL1-WDR4-IN-1 TFA inhibits the m 7G methyltransferase activity of the METTL1-WDR4 complex, blocking the m 7G modification of PKM mRNA, reducing PKM2 protein expression, disrupting the METTL1/PKM2/H3K9la positive feedback loop, and simultaneously inhibiting PKM2 nuclear translocation-mediated CD155 transcriptional activation. METTL1-WDR4-IN-1 TFA can inhibit tumor cell proliferation, weaken glycolytic metabolism, reverse tumor immune evasion (restoring NK cell and CD8 + T cell function), and regulate RNA epigenetic modification and the tumor immune microenvironment. METTL1-WDR4-IN-1 TFA can be used in immunotherapy research for cancers such as colorectal cancer, and is particularly suitable for use in combination with PKM2 inhibitors to enhance anti-tumor treatment efficacy .
    METTL1-WDR4-IN-1 TFA

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