1 Result for "

Z-Pro-Pro-CHO

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Z-Pro-Pro-CHO" in MCE Product Catalog:

Z-Pro-Pro-CHO
Z-Pro-Pro-CHO
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Cat. No.: HY-134454
CAS No.: 108708-25-4
Purity:  98.03%
Target:  

Prolyl Endopeptidase (PREP) Parasite

Research Areas:  

Infection

Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC50=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC50=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .
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