1 Result for "

androgen response element

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "androgen response element" in MCE Product Catalog:

Cat. No.: HY-117953
CAS No.: 155180-53-3
Target:  

Androgen Receptor

Research Areas:  

Cancer

RU 59063 is a high-affinity, selective nonsteroidal androgen receptor (AR) ligand that acts as a partial AR agonist/antagonist in CV-1 cell transcription assays. RU 59063 has a Ka value of 6.2×10 9 M -1 for human AR. RU 59063 induces a conformation of AR that can bind to the androgen response element (ARE), triggers partial AR-dependent transcriptional activation, and antagonizes testosterone-induced AR transcriptional activity. RU 59063 inhibits testosterone propionate-induced ornithine decarboxylase activity in mouse kidneys and testosterone propionate-induced prostate weight gain in rats. RU 59063 can be used in studies related to prostate cancer .
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