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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
anti-ferroptotic
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "anti-ferroptotic" in MCE Product Catalog:
Cat. No.: HY-W002942
CAS No.: 6640-50-2
Synonyms: 1,2,3,4-Tetrahydroquinolin-8-ol; 8-hydroxy-1,2,3,4-tetrahydroquinoline
Research Areas:
Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal I/R injury by suppressing ferroptosis and directly scavenging peroxyl radicals. Ferroptosis-IN-21 displays broad-spectrum anti-ferroptotic efficacy across multiple inducers in renal tubular epithelial cells, with nanomolar potency and robust suppression of lipid Reactive Oxygen Species (ROS). Ferroptosis-IN-21 significantly ameliorates renal I/R injury in mice, reducing histological damage, functional impairment, and inflammatory cytokine expression, while decreasing lipid peroxidation biomarkers such as 4-hydroxynonenal. Ferroptosis-IN-12 can be used for research in the field of ferroptosis-targeted drug development .
Cat. No.: HY-176914
CAS No.: 3103487-72-2
Target:
Research Areas:
Myosin-IN-3 (Compound 4-1) is a pyrimidine ketone derivative. Myosin-IN-3 exhibits significant anti ferroptotic activity (IC50 = 3.11 μM) while possessing myosin (IC50 = 3.09 μM) inhibitory activity and antioxidant activity (DPPH EC50 = 23.17 μM; MDA EC50 = 55.34 μM). Myosin-IN-3 can be used for research on heart conditions such as hypertrophic cardiomyopathy .
Cat. No.: HY-184508
Target:
Research Areas:
E3 ligase Ligand 81 is a VHL E3 ubiquitin ligase ligand and constitutes the VHL ligand moiety of R4VPL3-1 (HY-184506). R4VPL3-1 is a PROTAC-like bifunctional degrader linking RNF4 and VHL; it binds to and modifies GPX4, thereby inhibiting its anti-ferroptotic function. R4VPL3-1 induces iron-dependent lipid peroxidation and rapid ferroptosis-mediated cell death in cancer cells. E3 ligase Ligand 81 can be used in research related to targeted protein degradation and tumors such as melanoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
