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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
astrocyte function modulator
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "astrocyte function modulator" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: ONO-2506; (R)-2-Propyloctanoic acid
Research Areas:
Arundic Acid (ONO-2506; (R)-2-Propyloctanoic acid) is an orally active astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of astrocytic glutamate transporter EAAT1 by activating the ERK, Akt, and NF-κB pathways. Arundic Acid reduces retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid downregulates IL-1β, TNF-α, and ROS in a rat model of intracerebral hemorrhage, alleviating neuroinflammation, improving motor dysfunction, and reducing neuronal damage. Arundic Acid downregulates neuroinflammation and astrocyte dysfunction following status epilepticus in juvenile rats. Arundic Acid is used for research on Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage, and epilepsy .
Cat. No.: HY-107661R
CAS No.: 185517-21-9
Synonyms: ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)
Target:
Reference Standards ERK Akt NF-κB EAAT COX Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related
Research Areas:
Arundic Acid (Standard) (ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)) is the analytical standard of Arundic Acid (HY-107661). This product is intended for research and analytical applications. Arundic Acid (ONO-2506; (R)-2-Propyloctanoic acid) is an orally active astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of astrocytic glutamate transporter EAAT1 by activating the ERK, Akt, and NF-κB pathways. Arundic Acid reduces retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinson's disease. Arundic Acid downregulates IL-1β, TNF-α, and ROS in a rat model of intracerebral hemorrhage, alleviating neuroinflammation, improving motor dysfunction, and reducing neuronal damage. Arundic Acid downregulates neuroinflammation and astrocyte dysfunction following status epilepticus in juvenile rats. Arundic Acid is used for research on Parkinson's disease, cerebral ischemia, glaucoma, intracerebral hemorrhage, and epilepsy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
