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Results for "

c-Met kinase domain

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124761
    Poloppin

    		Polo-like Kinase (PLK) Autophagy Mitosis Cancer
    Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors .
    Poloppin
  • HY-157551
    JNK-IN-16

    		JNK c-Met/HGFR Cancer
    JNK-IN-16 is a c-Met and JNK inhibitor with nanomolar potency, with IC50 values of 120 nM and 72 nM, respectively. JNK-IN-16 can be used for cancer research .
    JNK-IN-16
  • HY-183672
    c-Met-IN-28

    		c-Met/HGFR Cancer
    c-Met-IN-28 is a type III allosteric inhibitor of c-MET, with pKi values of 7.4 (WT) and 7.1 (D1228V), and IC50 values of 37 nM (WT) and 72 nM (D1228V) against human c-MET. c-Met-IN-28 can be used for research on c-MET-driven cancers .
    c-Met-IN-28

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