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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
calcium-independent
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "calcium-independent" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: (6E)-Bromoenol lactone
Target:
Research Areas:
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca 2+ influx .
2
2 Cited Publications
Target:
Research Areas:
FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes .
1
1 Cited Publications
Cat. No.: HY-P704076
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; calcium-independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; IPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P71145
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; Peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic calcium-independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; Liver 2D
Species:
Human
Source:
E. coli
Synonyms: (S)-BEL; (S,E)-Bromoenol lactone
Target:
Research Areas:
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages .
Cat. No.: HY-116018
CAS No.: 1071000-98-0
Target:
Research Areas:
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis .
Cat. No.: HY-117068
CAS No.: 478288-90-3
Synonyms: (R,E)-Bromoenol lactone
Target:
Research Areas:
(R)-Bromoenol lactone ((R,E)-Bromoenol lactone) is an isomer of Bromoenol lactone (HY-107411). (R)-Bromoenol lactone acts as a selective inhibitor of microsomal calcium-independent phospholipase A2γ (iPLA2γ). (R)-Bromoenol lactone induces mild activation of p38 mitogen-activated protein kinase in prostate cancer cells, resulting in slight increases in the expressions of phosphorylated p53, total p53 and p21. (R)-Bromoenol lactone is applicable to prostate cancer-related research .
Cat. No.: HY-129944
CAS No.: 199106-13-3
Target:
Research Areas:
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Cat. No.: HY-101013
CAS No.: 79032-48-7
Synonyms: S-Nitroso-N-acetylpenicillamine
Cat. No.: HY-137103
CAS No.: 176767-94-5
Cat. No.: HY-129944A
CAS No.: 1135306-36-3
Target:
Research Areas:
MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Target:
Research Areas:
GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders .
[The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
[The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
Cat. No.: HY-117068S
Synonyms: (R,E)-Bromoenol lactone-d7
Research Areas:
(R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is the deuterated-labeled (R)-Bromoenol lactone (HY-117068). (R)-Bromoenol lactone ((R,E)-Bromoenol lactone) is an isomer of Bromoenol lactone (HY-107411). (R)-Bromoenol lactone acts as a selective inhibitor of microsomal calcium-independent phospholipase A2γ (iPLA2γ). (R)-Bromoenol lactone induces mild activation of p38 mitogen-activated protein kinase in prostate cancer cells, resulting in slight increases in the expressions of phosphorylated p53, total p53 and p21. (R)-Bromoenol lactone is applicable to prostate cancer-related research .
Cat. No.: HY-P811692
Synonyms: KIAA0768, LEC3, LPHN3, ADGRL3, Adhesion G protein-coupled receptor L3, calcium-independent alpha-latrotoxin receptor 3, Latrophilin-3, Lectomedin-3, CIRL-3
Cat. No.: HY-P704075
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; calcium-independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; IPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
HEK293
Cat. No.: HY-P790076
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; Peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic calcium-independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; Liver 2D
Species:
Mouse
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
