Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
casein kinase 1ε
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "casein kinase 1ε" in MCE Product Catalog:
8
8 Publications Verification
Target:
Research Areas:
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.
5
5 Cited Publications
Synonyms: TGR-1202; RP5264
Target:
Research Areas:
Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] .
5
5 Cited Publications
Synonyms: TGR-1202 hydrochloride; RP5264 hydrochloride
Target:
Research Areas:
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] .
2
2 Cited Publications
Target:
Research Areas:
IWP-4 is a Wnt inhibitor with an IC50 of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC50 of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC50 = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure [1] .
1
1 Cited Publications
Target:
Research Areas:
CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC50 of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis [1].
Cat. No.: HY-148233S
CAS No.: 2765264-50-2
Cat. No.: HY-171278
CAS No.: 1095750-94-9
Target:
Research Areas:
Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC50 of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% [1].
Cat. No.: HY-171277
CAS No.: 1095706-65-2
Target:
Research Areas:
Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC50s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC50 of 10 nM [1].
Cat. No.: HY-12279A
CAS No.: 1532533-72-4
Synonyms: TGR-1202 tosylate; RP5264 tosylate
Target:
Research Areas:
Umbralisib (TGR-1202) tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach [1] .
Cat. No.: HY-12279B
CAS No.: 1532533-75-7
Synonyms: TGR-1202 sulfate; RP-5264 sulfate
Target:
Research Areas:
Umbralisib (TGR-1202) sulfate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib sulfate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib sulfate can be used for haematological malignancies reseach [1] .
Cat. No.: HY-171279
CAS No.: 1177418-39-1
Target:
Research Areas:
Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC50 of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88 [1].
Cat. No.: HY-12279CR
CAS No.: 1532533-78-0
Synonyms: TGR-1202 hydrochloride (Standard); RP5264 hydrochloride (Standard)
Target:
Research Areas:
Umbralisib (hydrochloride) (Standard) is the analytical standard of Umbralisib (hydrochloride). This product is intended for research and analytical applications. Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] .
Cat. No.: HY-12279R
CAS No.: 1532533-67-7
Synonyms: TGR-1202 (Standard); RP5264 (Standard)
Target:
Research Areas:
Umbralisib (Standard) is the analytical standard of Umbralisib. This product is intended for research and analytical applications. Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] .
Cat. No.: HY-123859
CAS No.: 1454584-91-8
Target:
Research Areas:
SR-2890 is a highly selective, ATP-competitive inhibitor of casein kinase CK1δ and CK1ε, with IC50 values of 4 nM and 44 nM, respectively, and a Ki of 14 nM for CK1δ. SR-2890 exhibits antiproliferative effects. SR-2890 blocks the serine/threonine kinase activity of CK1δ and weakly inhibits a few off-target kinases such as FLT3, CDK4. SR-2890 has an oral bioavailability of 10% and a blood-brain barrier penetration rate of <1%. SR-2890 demonstrates stable in vitro metabolism and favorable in vivo pharmacokinetic properties, effectively inhibiting the growth of human A375 melanoma cells. SR-2890 can be used in melanoma research and is also a useful compound for studying CK1δ/ε-related diseases such as Alzheimer's disease [1].
Cat. No.: HY-P72152
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1E; Non-Specific Serine/Threonine Protein kinase; casein kinase 1 Epsilon; Alternative Protein CSNK1E; CKIepsilon; casein kinase 1, Epsilon; HCKIE; CKI-Epsilon; CKIE; CKIe; casein kinase I Isoform Epsilon
Species:
Human
Source:
E. coli
Cat. No.: HY-P705796
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1E; Non-Specific Serine/Threonine Protein kinase; casein kinase 1 Epsilon; Alternative Protein CSNK1E; CKIepsilon; casein kinase 1, Epsilon; HCKIE; CKI-Epsilon; CKIE; CKIe; casein kinase I Isoform Epsilon
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P702666
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1E; Non-Specific Serine/Threonine Protein kinase; casein kinase 1 Epsilon; Alternative Protein CSNK1E; CKIepsilon; casein kinase 1, Epsilon; HCKIE; CKI-Epsilon; CKIE; CKIe; casein kinase I Isoform Epsilon
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-111820R
CAS No.: 1784751-20-7
Target:
Research Areas:
CK1-IN-1 (Standard) is the analytical standard of CK1-IN-1 (HY-111820). This product is intended for research and analytical applications. CK1-IN-1 (Compound 1c) is a casein Kinase 1 (CK1) inhibitor with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC50 of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis [1].
Cat. No.: HY-12879G
CAS No.: 686772-17-8
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
