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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
cholesterol 7α-hydroxylase
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "cholesterol 7α-hydroxylase" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-104081
CAS No.: 11041-12-6
Synonyms: Cholestyramine resin; Colestyramine
Research Areas:
Cholestyramine (Cholestyramine resin) is an orally active bile acid sequestrant. Cholestyramine upregulates the expression of intestinal Apical sodium-dependent bile acid transporter and hepatic Cholesterol 7α-hydroxylase. Cholestyramine induces the expression of intestinal and hepatic cholesterol synthesis genes as well as hepatic lipogenesis genes, and promotes bile acid- and neutral sterol-mediated reverse cholesterol transport. Cholestyramine reduces intestinal cholesterol absorption and induces cholesterol efflux. Cholestyramine is applicable to research related to coronary artery disease, atherosclerotic cardiovascular disease and atherosclerosis .
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Category:
Target:
1
1 Cited Publications
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GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .
Cat. No.: HY-W008226
CAS No.: 480-66-0
Synonyms: 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone
Category:
Metabolic Disease Plants Curcuma comosa Roxb. Infection other families Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Zingiberaceae
Target:
Target:
Cat. No.: HY-B2012
CAS No.: 85509-19-9
Synonyms: DPX-H6573
Target:
Research Areas:
Flusilazole (DPX-H6573) is a broad-spectrum fungicide and cytochrome P-450 inhibitor that can be used in studies related to fungal infections .
Synonyms: cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol
Target:
Research Areas:
5β,6β-epoxycholestanol (Cholesterol 5β,6β-epoxide; 5β,6β-Epoxycholesterol) is an oxysterol. 5β,6β-epoxycholestanol induces cytotoxicity in bronchial epithelial cells. 5β,6β-epoxycholestanol induces lactate dehydrogenase (LDH) release and apoptosis in lymphoma cells undergoing macrophage differentiation . 5β,6β-epoxycholestanol is applicable to research related to atherosclerosis .
Cat. No.: HY-117147
CAS No.: 1438071-12-5
Target:
Research Areas:
GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .
Cat. No.: HY-105191
CAS No.: 143393-27-5
Synonyms: RS-21607
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Research Areas:
Azalanstat (RS-21607) is an orally active lanosterol 14α-demethylase inhibitor. Azalanstat exerts a cholesterol-lowering effect by inhibiting cholesterol synthesis and regulating HMG-CoA Reductase (HMGCR), and shows an additive effect when used in combination with Cholestyramine (HY-104081). Azalanstat is used in the study of hypercholesterolemia .
Cat. No.: HY-113342R
CAS No.: 566-28-9
Category:
Target:
Research Areas:
Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia .
Cat. No.: HY-P702798
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CYP7A1; CYPVII; Prev. CYP7; Cytochrome P450, Subfamily VIIA Polypeptide 1; Cytochrome P450, Family 7, Subfamily A, Polypeptide 1; cholesterol 7 Alpha-Monooxygenase; 24-Hydroxycholesterol 7-Alpha-hydroxylase; cholesterol 7alpha-hydroxylase; cholesterol 7-A
Species:
Human
Source:
E. coli
Cat. No.: HY-P85425
Synonyms: CYP7A1; CYP7; cholesterol 7-alpha-monooxygenase; CYPVII; cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1
Cat. No.: HY-101812R
CAS No.: 56488-59-6
Research Areas:
Terbufibrol (Standard) is the analytical standard of Terbufibrol (HY-101812). This product is intended for research and analytical applications. Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia .
Cat. No.: HY-105191A
CAS No.: 143484-82-6
Synonyms: RS-21607 dihydrochloride
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Research Areas:
Azalanstat (RS-21607) dihydrochloride is an orally active lanosterol 14α-demethylase inhibitor. Azalanstat dihydrochloride exerts a cholesterol-lowering effect by inhibiting cholesterol synthesis and regulating HMG-CoA Reductase (HMGCR), and shows an additive effect when used in combination with Cholestyramine (HY-104081). Azalanstat dihydrochloride is used in the study of hypercholesterolemia .
Cat. No.: HY-105191C
CAS No.: 143484-80-4
Synonyms: RS-21607 mesylate
Target:
Research Areas:
Azalanstat (RS-21607) mesylate is an orally active lanosterol 14α-demethylase inhibitor. Azalanstat mesylate exerts a cholesterol-lowering effect by inhibiting cholesterol synthesis and regulating HMG-CoA Reductase (HMGCR), and shows an additive effect when used in combination with Cholestyramine (HY-104081). Azalanstat mesylate is used in the study of hypercholesterolemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
