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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
closed conformation of the lid domain
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "closed conformation of the lid domain" in MCE Product Catalog:
Cat. No.: HY-189484
CAS No.: 64552-26-7
Target:
Research Areas:
MGL-IN-4 (compound 16) is a covalent monoacylglycerol lipase (MGL) inhibitor with an IC50 of 7.8 nM against hMGL. MGL-IN-4 covalently modifies a key cysteine residue of MGL through ring-opening release of an active sulfur atom, locking the lid domain in a closed conformation to allosterically inhibit its activity. MGL-IN-4 can be used in studies of neuroprotection and anti-inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
