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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
collagen production
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "collagen production" in MCE Product Catalog:
57
57 Publications Verification
Cat. No.: HY-123606
CAS No.: 1652629-23-6
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GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 + T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .
3
3 Cited Publications
Synonyms: Cerulomycin; Caerulomycin
Category:
Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Inflammation/Immunology Other Antibiotics
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2
2 Cited Publications
Cat. No.: HY-P4846
CAS No.: 292171-04-1
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2
Category:
other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Cat. No.: HY-E70005H
CAS No.: 9001-12-1
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Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis .
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1
1 Cited Publications
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VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production .
1
1 Cited Publications
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SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) .
1
1 Cited Publications
Cat. No.: HY-A0169A
CAS No.: 79416-27-6
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Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .
1
1 Cited Publications
Cat. No.: HY-N2589
CAS No.: 19416-87-6
Category:
Vaccaria segetalis (Neck.) Garcke Flavonoids Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae
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Cat. No.: HY-168625
CAS No.: 3050683-38-7
Synonyms: VAV1 degrader-3
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MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. .
Cat. No.: HY-158231
Synonyms: F127DA
Category:
Microorganisms Santalum album Linn. Ketones, Aldehydes, Acids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Santalaceae
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Cat. No.: HY-P3163
CAS No.: 885024-94-2
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Cat. No.: HY-P0104
CAS No.: 1447824-23-8
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Cat. No.: HY-155487
CAS No.: 1404380-58-0
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JTE-151 is an orally active, selective RORγ antagonist with IC50 values of 20.6 nM, 41.8 nM and 32.2 nM against hRORγ, rRORγ and mRORγ, respectively . JTE-151 reduces the production of IL-17. JTE-151 alleviates paw swelling and bone destruction in arthritis models. JTE-151 can be used in research related to rheumatoid arthritis, collagen-induced arthritis, experimental autoimmune encephalomyelitis, psoriasis, multiple sclerosis and inflammatory bowel disease .
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RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 (hTAAR1) with a Ki of 0.3 nM. RTI-7470-44 inhibits hTAAR1-mediated cAMP production and signal transduction (IC50 = 8.4 nM), and blocks hTAAR1-mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying .
Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:
Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Other Flavonoids
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Cat. No.: HY-P11087
CAS No.: 134335-45-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
