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Results for "

cruzain

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119293
    K777
    3 Publications Verification

    		 Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus Infection Inflammation/Immunology Cancer
    K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
    K777
  • HY-10836
    Cruzain-IN-1

    		Parasite Others
    Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.
    Cruzain-IN-1
  • HY-119293A
    K777 tosylate

    		Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus Infection Inflammation/Immunology Cancer
    K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
    K777 tosylate
  • HY-118338
    WRR-483

    		Parasite Infection
    WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.
    WRR-483
  • HY-159915
    Se2h

    		Parasite Infection
    Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 < 1 μM, SI > 10), with an inhibitory activity against cruzain of IC50 < 100 nM (SI > 5.55). Compared to Benznidazole (HY-B1548) and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease .
    Se2h
  • HY-10836R
    Cruzain-IN-1 (Standard)

    		Reference Standards Parasite Others
    Cruzain-IN-1 (Standard) is the analytical standard of Cruzain-IN-1 (HY-10836). This product is intended for research and analytical applications. Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.
    Cruzain-IN-1 (Standard)
  • HY-168732
    MCG-02

    		Parasite Infection
    MCG-02 is the inhibitor for cruzain (CRZ) and cathepsin L-like protease (CATL), that inhibits the CRZ in Trypanosoma cruzi and CATL in Trypanosoma brucei with the IC50 0.2 μM and 0.02 μM .
    MCG-02
  • HY-183747
    Antitrypanosomal agent 32

    		Parasite Infection
    Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection .
    Antitrypanosomal agent 32

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