2. Anti-infection
  3. Parasite
  4. Cruzain-IN-1

Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.

For research use only. We do not sell to patients.

Cruzain-IN-1 Chemical Structure

Cruzain-IN-1 Chemical Structure

CAS No. : 1199523-24-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 165 In-stock
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10 mg USD 240 In-stock
50 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.

IC50 & Target

Trypanosoma

10 nM (IC50)

Molecular Weight

300.27

Formula

C14H10F2N6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN1C2=NC(C#N)=NC(NC3=CC(F)=CC(F)=C3)=C2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (83.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3303 mL 16.6517 mL 33.3034 mL
5 mM 0.6661 mL 3.3303 mL 6.6607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3303 mL 16.6517 mL 33.3034 mL 83.2584 mL
5 mM 0.6661 mL 3.3303 mL 6.6607 mL 16.6517 mL
10 mM 0.3330 mL 1.6652 mL 3.3303 mL 8.3258 mL
15 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
20 mM 0.1665 mL 0.8326 mL 1.6652 mL 4.1629 mL
25 mM 0.1332 mL 0.6661 mL 1.3321 mL 3.3303 mL
30 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
40 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
50 mM 0.0666 mL 0.3330 mL 0.6661 mL 1.6652 mL
60 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3876 mL
80 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0407 mL
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Cruzain-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cruzain-IN-11199523-24-4ParasiteInhibitorinhibitorinhibit

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