Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
dark cytotoxicity
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "dark cytotoxicity" in MCE Product Catalog:
Cat. No.: HY-161668
Target:
Research Areas:
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively .
Cat. No.: HY-W698583A
CAS No.: 214211-69-5
Target:
Research Areas:
BNN5Na is a guanylate cyclase activator and vasorelaxant inducer. BNN5Na undergoes photolytic uncaging to release nitric oxide. BNN5Na remains stable in pH 7.4 phosphate buffer at 37°C for over 1 day in the dark and does not react noticeably with cysteine under these conditions. BNN5Na is water-soluble but membrane-impermeant, remaining in extracellular aqueous compartments. BNN5Na shows no cytotoxicity toward rat aortic strip contractile apparatus .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
