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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
double-prodrug
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "double-prodrug" in MCE Product Catalog:
Cat. No.: HY-187608
CAS No.: 144412-18-0
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Research Areas:
Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin αIIbβ3) inhibitor with an IC50 of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis .
Cat. No.: HY-185215
CAS No.: 1770840-57-7
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GS-646089 is a broad-spectrum antiviral nucleoside analog that exhibits significant inhibitory activity against respiratory syncytial virus (RSV), human metapneumovirus (hMPV), rhinovirus (enterovirus) and enteroviruses. The IC50 of GS-646089 targeting RNA-dependent RNA polymerase (RdRp) ranges from 43 to 46 nM. GS-646089 blocks viral replication by being converted into a triphosphate metabolite intracellularly, which competes with ATP for incorporation into nascent RNA strands and acts as an immediate chain terminator. GS-646089 is the parent compound of the double prodrug GS-7682 (HY-161877), and is used in studies of acute respiratory viral infections and infections caused by related pathogens .
Cat. No.: HY-187221
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Research Areas:
Anti-SARS-CoV-2 agent prodrug-1 is a double prodrug modified with 5'-ProTide and N 4-propionyl ester, exhibiting anti-SARS-CoV-2 activity (EC50 = 3.22 μM). Anti-SARS-CoV-2 agent prodrug-1 is rapidly converted by esterases into intermediate 4, which has stronger plasma metabolic stability and can be rapidly activated to exert antiviral effects. Anti-SARS-CoV-2 agent prodrug-1 shows anti-SARS-CoV-2 activity in vitro and exhibits low cytotoxicity. Anti-SARS-CoV-2 agent prodrug-1 can be used in studies related to SARS-CoV-2 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
