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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
esculetin
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "esculetin" in MCE Product Catalog:
8
Category:
Oleaceae Fraxinus rhynchophylla Hance Coumarins Phenols Polyphenols Phenylpropanoids Plants
Target:
Cat. No.: HY-121231R
CAS No.: 501-16-6
Target:
Cat. No.: HY-105140
CAS No.: 169673-60-3
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Research Areas:
CPA 926 is a prodrug of Esculetin (HY-N0284) and is orally active. CPA 926 can inhibit the production of MMP in cartilage explants. CPA 926 can be used for the research of inflammation, such as experimental osteoarthritis .
Cat. No.: HY-W471938
CAS No.: 82747-36-2
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Antiproliferative agent-35 (Compound 4) is an anticancer agent derivated from Esculetin (HY-N0284). Antiproliferative agent-35 inhibits the proliferation of B16 and A549 cells, with IC50s of 13.2 and 9.2 μM resspectively .
Cat. No.: HY-184265
CAS No.: 1993461-76-9
Synonyms: Mito-Esc
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Mito-Esculetin (Mito-Esc) is an orally active mitochondria-targeted derivative of Esculetin (HY-N0284). Mito-Esculetin inhibits LPS-induced phosphorylation of STAT3 Tyr-705, partially reverses LPS-mediated depletion of SIRT3, and enhances the AMPK-SIRT1 signaling axis. Mito-Esculetin inhibits PAI-1 activity, regulates miRNA, and induces phosphorylation of IRS and AKT. Mito-Esculetin suppresses oxidant-induced endothelial dysfunction, Ang-II (HY-13948)- and high glucose-induced atherosclerotic plaque formation, Palmitate (HY-N0830)-induced insulin resistance, as well as high glucose-mediated endothelial cell senescence and inflammatory responses. Mito-Esculetin reduces body weight and non-esterified fatty acid (NEFA) levels. Mito-Esculetin can be used in research related to acute coronary syndrome, type 2 diabetes, and hyperglycemia-induced atherosclerosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
