4 Results for "

exosite

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "exosite" in MCE Product Catalog:

Cat. No.: HY-P99298
CAS No.: 1278466-20-8
Synonyms: RG 7417; TNX 234; Anti-CFD Recombinant Antibody

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .
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Cat. No.: HY-P991065
CAS No.: 2589583-20-8
Synonyms: JNJ-375; JNJ-64179375; JNJ-9375

Target:  

Thrombin

Research Areas:  

Cardiovascular Disease

Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P2021
CAS No.: 138828-04-3
Target:  

Thrombin

Research Areas:  

Cardiovascular Disease

BMS 180742 is a thrombin exosite inhibitor. BMS 180742 does not inhibit arterial thrombosis .
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Cat. No.: HY-P2490
CAS No.: 125441-00-1
Target:  

Thrombin

Research Areas:  

Metabolic Disease

Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex .
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