Ichorcumab
Based on 1 Customer Validation
Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
For research use only. We do not sell to patients.
- Purity : 95.33%
- CAS No.: 2589583-20-8
- Molecular Weight:146.260 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
Thrombin
In Vitro
Ichorcumab (JNJ‐9375) prolongs clotting times by binding to exosite 1 on thrombin and preventing its interaction with fibrinogen and other substrates such as factors V and VIII and protease activated receptor 1. Because Ichorcumab does not affect the catalytic activity of thrombin, Ichorcumab may produce less bleeding than anticoagulants that block the active site of thrombin or factor Xa[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
Chemical Information
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CAS No. 2589583-20-8
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Appearance Liquid
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Molecular Weight 146.260 kDa
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Color Colorless to light yellow
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SMILES
[Ichorcumab]
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Synonyms
JNJ-375; JNJ-64179375; JNJ-9375
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)