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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
186 Results for "
fibroblast growth factor receptor
" in MedChemExpress (MCE) Product Catalog:
Products (186)
186 Results for "fibroblast growth factor receptor" in MCE Product Catalog:
20
Category:
Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Monophenols Sunscreen Simple Phenylpropanols Phenols Cosmetic Research Phenylpropanoids Disease Research Fields Cancer
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20
20 Publications Verification
Cat. No.: HY-N0060A
CAS No.: 24276-84-4
Synonyms: Coniferic acid sodium
11
11 Cited Publications
BLU9931 is a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM. BLU9931 has significant antitumor activity .
7
Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively .
5
Fisogatinib (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 5 nM. Fisogatinib has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling .
4
Research Areas:
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity .
2
2 Cited Publications
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FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM and 3.2 nM, respectively. Antitumor activity .
2
2 Cited Publications
Cat. No.: HY-P990859
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1
1
1 Cited Publications
Cat. No.: HY-P70817
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGFR3; Mutant fibroblast growth factor receptor 3; Prev. ACH; fibroblast growth factor receptor 3-S; JTK4; fibroblast growth factor receptor; CD333; receptor Protein-Tyrosine Kinase; CEK2; Hydroxyaryl-Protein Kinase; FGFR-3; Tyrosine Kinase JTK4; Fibrobla
Species:
Human
Source:
HEK293
1
1
Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer . Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
1
1 Cited Publications
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(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure .
Cat. No.: HY-P3503
CAS No.: 1480724-61-5
Synonyms: BMN 111
Cat. No.: HY-P99010
CAS No.: 1952272-74-0
Synonyms: AMG-552; FPA-144
Cat. No.: HY-P3281
CAS No.: 499993-62-3
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CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3), with IC50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectively .
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SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer .
Cat. No.: HY-P99823
CAS No.: 2226238-09-9
Synonyms: TA-46; sFGFR3
Cat. No.: HY-170869
PROTAC FGFR1 degrader-1 is a PROTAC degrader targeting fibroblast growth factor receptor 1 (FGFR1), with a DC50 of 39.78 nM and an IC50 of 26.81 nM in KG1a cells. PROTAC FGFR1 degrader-1 selectively degrades FGFR1 via the ubiquitin-proteasome system, showing concentration- and time-dependent degradation in cancer cells. PROTAC FGFR1 degrader-1 can be used in studies related to leukemia and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
