186610-89-9
186610-89-9
Chemical Structure
SU4984
- CAS No.: 186610-89-9
- Formula:C20H19N3O2
- Molecular Weight:333.38
IUPAC Name: (Z)-4-(4-((2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde
InChIKey: ZNFJBJDODKHWED-AQTBWJFISA-N
SMILES: O=CN1CCN(CC1)C2=CC=C(C=C2)/C=C3C(NC4=C\3C=CC=C4)=O
Biological Activity: SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SU4984 | 99.70% | SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60. [Content Brief]
- [2]. Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4. [Content Brief]
Keywords
