2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Gunagratinib

Gunagratinib  (Synonyms: ICP-192)

Cat. No.: HY-132817 Purity: 99.36%
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Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer. Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Gunagratinib Chemical Structure

Gunagratinib Chemical Structure

CAS No. : 2211082-53-8

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2500 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
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Based on 1 publication(s) in Google Scholar

Gunagratinib Related Antibodies

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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Description

Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer[1]. Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

FGFR

 

In Vitro

Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gunagratinib Related Antibodies
Clinical Trial
Molecular Weight

423.47

Formula

C22H25N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CNC1=C(C(N)=O)C(C#CC2=CC(OC)=CC(OC)=C2)=NN1[C@]3([H])CN(CC3)C(C=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (236.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8072 mL 23.6144 mL
5 mM 0.4723 mL 2.3614 mL 4.7229 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3614 mL 11.8072 mL 23.6144 mL 59.0361 mL
5 mM 0.4723 mL 2.3614 mL 4.7229 mL 11.8072 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL 5.9036 mL
15 mM 0.1574 mL 0.7871 mL 1.5743 mL 3.9357 mL
20 mM 0.1181 mL 0.5904 mL 1.1807 mL 2.9518 mL
25 mM 0.0945 mL 0.4723 mL 0.9446 mL 2.3614 mL
30 mM 0.0787 mL 0.3936 mL 0.7871 mL 1.9679 mL
40 mM 0.0590 mL 0.2952 mL 0.5904 mL 1.4759 mL
50 mM 0.0472 mL 0.2361 mL 0.4723 mL 1.1807 mL
60 mM 0.0394 mL 0.1968 mL 0.3936 mL 0.9839 mL
80 mM 0.0295 mL 0.1476 mL 0.2952 mL 0.7380 mL
100 mM 0.0236 mL 0.1181 mL 0.2361 mL 0.5904 mL
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Gunagratinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gunagratinib2211082-53-8ICP-192ICP192ICP 192FGFRFibroblast growth factor receptorpotentlow-toxicityorallyactiveselectiveirreversiblecancerInhibitorinhibitorinhibit

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