2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGL peptide

FGL peptide is a fibroblast growth factor receptor (FGFR) modulator and blood-brain barrier-penetrant. FGL peptide activates NCAM-FGFR and FGFR1 signaling pathways. FGL peptide alters expression of apoptosis, signal transduction and metabolism regulator genes in traumatic brain injury contexts. FGL peptide can be used for the research of traumatic brain injury.

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FGL peptide

FGL peptide Chemical Structure

CAS No. : 499993-62-3

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FGL peptide Related Antibodies

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Description

FGL peptide is a fibroblast growth factor receptor (FGFR) modulator and blood-brain barrier-penetrant. FGL peptide activates NCAM-FGFR and FGFR1 signaling pathways. FGL peptide alters expression of apoptosis, signal transduction and metabolism regulator genes in traumatic brain injury contexts. FGL peptide can be used for the research of traumatic brain injury[1][2].

In Vivo

FGL peptide (10 mg/kg; s.c.; every third day) modulates global gene expression in both injured and non-injured adolescent male Wistar rats, with effects supporting neuroprotection, reduced degeneration, and enhanced cellular stability and regenerative processes[1].
FGL peptide (2.6-26.0 µg; i.n.; on PND1, 2, and 3) accelerates maturation of vestibular-dependent sensorimotor coordination skills in newborn Wistar rats, specifically reducing surface righting reflex latency and increasing successful negative geotaxis responses on PND4-6, without affecting general motor activity, muscle strength, or body weight[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, adolescent, 100 g, traumatic brain injury model via dry ice application to skull)[1]
Dosage: 10 mg/kg
Administration: s.c.; every third day
Result: Altered the expression of 82 genes via interaction with TBI in injured animals. Upregulated a gene cluster including Fas apoptotic inhibitory molecule, regulator of G-protein signaling 14, and solute carrier family 7 member 1 at 4 days post-injury. Modulated expression of genes involved in metabolism, transcription, and cytoskeleton maintenance, with some genes showing upregulation at 6 hours and 4 days but downregulation at 1 day post-injury. Upregulated genes encoding neurofilament, adenylate cyclase activating polypeptide 1, and RNA binding protein p45AUF1 in non-injured animals. Downregulated genes encoding RNA helicase II, mitochondrial ribosomal protein 9, and metaxin 2 in non-injured animals.
Molecular Weight

1649.80

Formula

C71H116N20O25
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Glu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala
Sequence Shortening

EVYVVAENQQGKSKA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (60.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6061 mL 3.0307 mL 6.0613 mL
5 mM 0.1212 mL 0.6061 mL 1.2123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6061 mL 3.0307 mL 6.0613 mL 15.1534 mL
5 mM 0.1212 mL 0.6061 mL 1.2123 mL 3.0307 mL
10 mM 0.0606 mL 0.3031 mL 0.6061 mL 1.5153 mL
15 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
20 mM 0.0303 mL 0.1515 mL 0.3031 mL 0.7577 mL
25 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6061 mL
30 mM 0.0202 mL 0.1010 mL 0.2020 mL 0.5051 mL
40 mM 0.0152 mL 0.0758 mL 0.1515 mL 0.3788 mL
50 mM 0.0121 mL 0.0606 mL 0.1212 mL 0.3031 mL
60 mM 0.0101 mL 0.0505 mL 0.1010 mL 0.2526 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FGL peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGL peptide499993-62-3FGFRFibroblast growth factor receptortraumatic brain injuryblood-brain barriernewborn ratsNCAM-FGFRadult ratsfibroblast growth factor receptorWistar ratsFGFR1 signaling pathwayscerebrospinal fluidInhibitorinhibitorinhibit

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