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Results for "

fluorescence intensity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (3) Apoptosis (1) Arf Family GTPase (1) Autophagy (3) Bacterial (2) Beta-secretase (1) Biochemical Assay Reagents (7) Calcium Channel (1) Caspase (2) CD74 (1) DNA Alkylator/Crosslinker (2) DNA Stain (13) DNA/RNA Synthesis (1) Environmental Pollutants (1) Fluorescent Dye (60) Glycosidase (1) Histone Acetyltransferase (1) HIV (1) Isotope-Labeled Compounds (1) Lipocalin Family (1) Liposome (1) MMP (3) p38 MAPK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sodium Channel (3) VSV (1)
By Research Areas:	Cancer (7) Infection (8) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (11)

By Targets:

Amyloid-β (3)

Apoptosis (1)

Arf Family GTPase (1)

Autophagy (3)

Bacterial (2)

Beta-secretase (1)

Biochemical Assay Reagents (7)

Calcium Channel (1)

Caspase (2)

CD74 (1)

DNA Alkylator/Crosslinker (2)

DNA Stain (13)

DNA/RNA Synthesis (1)

Environmental Pollutants (1)

Fluorescent Dye (60)

Glycosidase (1)

Histone Acetyltransferase (1)

HIV (1)

Isotope-Labeled Compounds (1)

Lipocalin Family (1)

Liposome (1)

MMP (3)

p38 MAPK (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

Sodium Channel (3)

VSV (1)

By Research Areas:

Cancer (7)

Infection (8)

Inflammation/Immunology (5)

Metabolic Disease (1)

Neurological Disease (11)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15559

Hoechst 33342 140+ Cited Publications bisBenzimide H 33342; HOE 33342	Autophagy	Others
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0814

DAPI dihydrochloride Maximum Cited Publications 146 Publications Verification 4',6-Diamidino-2-phenylindole dihydrochloride	DNA Stain Sodium Channel	Neurological Disease
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

HY-W019823

4-MUNANA 2 Publications Verification	Fluorescent Dye	Infection Neurological Disease
4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-D0090

MQAE 15+ Cited Publications	Fluorescent Dye	Others
MQAE is a chloride ion (Cl ^-) fluorescent probe that can be used to measure chloride concentrations. The fluorescence intensity of MQAE decreases proportionally as Cl ^- ions increase. MQAE has high cell permeability and is suitable for fluorescence detection such as confocal microscopy and flow cytometry (Ex/Em=350/460 nm) .

HY-15559A

Hoechst 33342 trihydrochloride 140+ Cited Publications bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride	Autophagy	Others
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0856

Bis-Tris	Biochemical Assay Reagents	Others
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

HY-W751238

Dimethyl methylene blue zinc chloride double salt DMMB	Fluorescent Dye	Others
Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye. Dimethyl methylene blue zinc chloride double salt competitively binds to the active site of the PANI-Benz-Ag nanocomposite with endotoxin, releasing DMMB and increasing the fluorescence intensity. Dimethyl methylene blue zinc chloride double salt can be used as a fluorescent probe for the detection of bacteria (such as E. Coli) endotoxin . Dimethyl methylene blue zinc chloride double salt can be used for the quantification of sulfated glycosaminoglycans .

HY-NP008

β-Lactoglobulin	Lipocalin Family	Inflammation/Immunology
β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-15558A

Hoechst 33258 trihydrochloride 20+ Cited Publications bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride	Fluorescent Dye	Cancer
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15558

Hoechst 33258 20+ Cited Publications bisBenzimide H 33258; H 33258	Fluorescent Dye DNA Stain DNA Alkylator/Crosslinker	Others
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .

HY-B2235B

L-α-Lecithin (egg yolk, Type XVI-E), 99% L-α-Phosphatidylcholine (egg yolk, Type XVI-E), 99%, lyophilized powder; 1,2-Diacyl-sn-glycero-3-phosphocholine (egg yolk, Type XVI-E), 99%; egg yolk Lecithins, Type XVI-E, 99%	Environmental Pollutants Biochemical Assay Reagents Liposome	Others
L-α-Lecithin (egg yolk, Type XVI-E), 99% (L-α-Phosphatidylcholine (egg yolk, Type XVI-E), 99%) is an active biomaterial. L-α-Lecithin (egg yolk, Type XVI-E), 99% forms liposomes with compounds (PF or BA). L-α-Lecithin (egg yolk, Type XVI-E), 99% increases membrane fluidity and affects microemulsion stability and fluorescence intensity stained with Nile red (HY-D0718). L-α-Lecithin (egg yolk, Type XVI-E), 99% It can be used for cell membrane structure research, biological membrane potential research, and liposome research .

HY-W074143

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride 5+ Cited Publications	Fluorescent Dye	Others
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] ²⁺) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S₂O₈ ^2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research .

HY-153006

2,7-Dichlorodihydrofluorescein 5+ Cited Publications DCFH2	Biochemical Assay Reagents	Others
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H₂O₂, ONOO ^-, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) .

HY-D1738

DAPI dilactate 110+ Cited Publications 4',6-Diamidino-2-phenylindole dilactate	Fluorescent Dye	Others
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .

HY-D2189

IR 700DX IR 700DX NHS ester	Fluorescent Dye	Others
IR 700DX (IR 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IR 700DX binds to biomolecules. IR 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IR 700DX can be used as a highly flexible photosensitizer .

HY-D0031

8-Aminopyrene-1,3,6-trisulfonic acid trisodium APTS	Fluorescent Dye	Others
8-Aminopyrene-1,3,6-trisulfonic acid trisodium (APTS) is an anionic fluorescent dye (excitation/emission: 425/503 nm in pH 7.4 PBS). The fluorescence intensity of 8-Aminopyrene-1,3,6-trisulfonic acid trisodium remains stable at pH 4-10. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium retains its fluorescence properties when immobilized in a hydrogel by copolymerization. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium can be used for glucose sensing .

HY-D1425

DCVJ 9-(2,2-Dicyanovinyl)julolidine	Fluorescent Dye	Others
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells (Absorption/emission=489/505 nm) .

HY-DY1005

Hoechst 33342 trihydrochloride (solution)	Autophagy	Others
Hoechst 33342 trihydrochloride (solution) is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution . Solvent and Concentration: Sterile water: 10 mg/mL

HY-W250727

TNS sodium 1 Publications Verification 6-(p-Tolylamino)naphthalene-2-sulfonate sodium	Fluorescent Dye	Others
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-W013967

1,6-Diphenylhexa-1,3,5-triene	Fluorescent Dye	Infection
1,6-Diphenylhexa-1,3,5-triene is a membrane intercalator and hydrophobic fluorescent probe. 1,6-Diphenylhexa-1,3,5-triene intercalates into the non-polar region of lipid bilayers of adipocyte membranes with probe/membrane equilibrium affected by temperature, probe concentration, and membrane concentration. 1,6-Diphenylhexa-1,3,5-triene’s fluorescence intensity correlating with adipocyte membrane probe incorporation (Ex/Em = 350/452 nm) .

HY-15560

Hoechst 34580 5 Publications Verification HOE 34580	Amyloid-β	Neurological Disease
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15560B

Hoechst 34580 tetrahydrochloride 5 Publications Verification HOE 34580 tetrahydrochloride	Amyloid-β	Neurological Disease
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1359

Mito Red 1 Publications Verification	Fluorescent Dye	Others
Mito Red is a vital dye and mitochondrial stain that can be used to detect and evaluate mitochondrial function and status. Mito Red accumulates in mitochondria, and its fluorescence intensity is positively correlated with mitochondrial membrane potential. When the mitochondrial membrane potential increases, the fluorescence signal of Mito Red increases .

HY-D2868

DAPI 130+ Cited Publications 4',6-Diamidino-2-phenylindole	DNA Stain Sodium Channel	Neurological Disease
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

HY-D1631

Calcium Green-5N AM	Fluorescent Dye Calcium Channel	Neurological Disease
Calcium Green-5N AM is a Ca ²⁺-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-W105681

Bis-Tris hydrochloride	Biochemical Assay Reagents	Others
Bis-Tris hydrochloride is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris hydrochloride can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

HY-D0077

2',7'-Difluorofluorescein Oregon green 488	Fluorescent Dye	Others
2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pK_a ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca ²⁺ indicators, a fluorescent imaging agent, and an anisotropy probe .

HY-15627

Hoechst 33342 analog 5 Publications Verification	Fluorescent Dye	Others
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15623

Hoechst 33258 analog 1 Publications Verification	DNA Stain	Others
Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15619

Hoechst S 769121 Nuclear yellow	Fluorescent Dye	Others
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-D1191

SYBR green I chloride 3 Publications Verification	Fluorescent Dye DNA/RNA Synthesis	Others
SYBR Green I chloride is a highly sensitive fluorescent nucleic acid dye that binds specifically to the minor groove of double-stranded DNA or intercalates between base pairs. SYBR Green I chloride exhibits weak fluorescence in the unbound state but emits bright fluorescence upon binding, and it preferentially binds to large-fragment DNA and DNA with high G+C content. SYBR Green I chloride is suitable for real-time PCR technology; its fluorescence intensity correlates with the amount and size of amplification products, enabling accurate quantification of gene expression and discrimination of amplicons via melting curve analysis without additional post-processing. SYBR Green I chloride is widely used in preclinical in vitro nucleic acid detection .

HY-15631

Hoechst 33258 analog 6 5+ Cited Publications	Fluorescent Dye	Others
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution (Ex/Em = 356/451 nm) .

HY-D0916

Thiazole orange dimer YOYO 1 YOYO 1; YOYO1	Fluorescent Dye	Others
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-DY1034

4-MUNANA (solution)	Fluorescent Dye	Infection Neurological Disease
4-MUNANA (solution) is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses . Solvent and Concentration: Sterile water: 10 mM

HY-15630A

Hoechst 33342 analog 2 trihydrochloride 1 Publications Verification	Fluorescent Dye	Others
Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0110A

Fura-2 pentapotassium	Fluorescent Dye	Others
Fura-2 pentapotassium is a cell-impermeable scaled fluorescent dye that can be used for intracellular calcium imaging. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca ²⁺ level .

HY-D1556

18:1 PE CF 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium	Fluorescent Dye	Cancer
18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .

HY-148796

Rizedisben GE3126	Fluorescent Dye	Others
Rizedisben (GE3126) is a fluorophore that can be used in fluorescence image-guided surgery. Rizedisben reduces non-specific adipose tissue fluorescence intensity and enhances nerve visibility .

HY-15562

HOE 32021	Fluorescent Dye	Others
HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15561B

HOE-S 785026 trihydrochloride meta-Hoechst trihydrochloride	Fluorescent Dye	Others
HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1631A

Calcium green-5N hexapotassium	Fluorescent Dye	Neurological Disease
Calcium green-5N hexapotassium is a cell-impermeant Ca ²⁺-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-D2476

H2S Fluorescent probe 1	Fluorescent Dye	Others
H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe that detects hydrogen sulfide (H₂S) with almost no cytotoxicity. Upon the addition of increasing amounts of HS ^- to DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears gradually at 485 nm. H2S Fluorescent probe 1, the fluorescence intensity notes at 434 nm increasing rapidly by titration of HS ^- .

HY-D3010

VF dsDNA Green Dye	Fluorescent Dye	Others
VF dsDNA Green Dye is a fluorescent dye for detecting and quantifying double-stranded DNA (dsDNA). VF dsDNA Green Dye fluoresces only when bound to dsDNA, and the fluorescence intensity is proportional to the DNA concentration. VF dsDNA Green Dye does not fluoresce when bound to ssDNA, RNA, or free nucleotides. VF dsDNA Green Dye can detect dsDNA within the range of 25 pg/mL to 1000 ng/mL (Ex/Em = 480/520 nm).

HY-15629

HOE 32020	DNA Stain	Others
HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15628

Hoechst 33258 analog 5	DNA Stain	Others
Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15630

Hoechst 33342 analog 2	Fluorescent Dye	Cancer
Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1515

FM1-84 Neurodye GH1-84	Fluorescent Dye	Neurological Disease
FM1-84 (Neurodye GH1-84) is a fluorescent dye. FM1-84 has lipophilic and facilitates association with membranes, resulting in an increase in fluorescence intensity (λ_ex=510 nm, λ_em=625 nm). FM1-84 can be used for synaptic vesicle recycling in neurons research .

HY-W127781

Rhod-2 triammonium	Fluorescent Dye	Others
Rhod-2 triammonium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 triammonium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift .

Cat. No.	Product Name	Type

HY-15559

Hoechst 33342

140+ Cited Publications

bisBenzimide H 33342; HOE 33342

Fluorescent Dyes

Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0814

DAPI dihydrochloride

Maximum Cited Publications

146 Publications Verification

4',6-Diamidino-2-phenylindole dihydrochloride

Fluorescent Dyes

DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

HY-W019823

4-MUNANA

2 Publications Verification

Fluorescent Dyes

4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-D0090

MQAE 15+ Cited Publications	Fluorescent Dyes
MQAE is a chloride ion (Cl ^-) fluorescent probe that can be used to measure chloride concentrations. The fluorescence intensity of MQAE decreases proportionally as Cl ^- ions increase. MQAE has high cell permeability and is suitable for fluorescence detection such as confocal microscopy and flow cytometry (Ex/Em=350/460 nm) .

HY-15559A

Hoechst 33342 trihydrochloride

140+ Cited Publications

bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride

Fluorescent Dyes

Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-W751238

Dimethyl methylene blue zinc chloride double salt

DMMB

Fluorescent Dyes

Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye. Dimethyl methylene blue zinc chloride double salt competitively binds to the active site of the PANI-Benz-Ag nanocomposite with endotoxin, releasing DMMB and increasing the fluorescence intensity. Dimethyl methylene blue zinc chloride double salt can be used as a fluorescent probe for the detection of bacteria (such as E. Coli) endotoxin . Dimethyl methylene blue zinc chloride double salt can be used for the quantification of sulfated glycosaminoglycans .

HY-15558A

Hoechst 33258 trihydrochloride

20+ Cited Publications

bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride

Fluorescent Dyes

Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15558

Hoechst 33258

20+ Cited Publications

bisBenzimide H 33258; H 33258

Fluorescent Dyes

Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .

HY-W074143

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride

5+ Cited Publications

Fluorescent Dyes

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] ²⁺) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S₂O₈ ^2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research .

HY-D1738

DAPI dilactate

110+ Cited Publications

4',6-Diamidino-2-phenylindole dilactate

Fluorescent Dyes

DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .

HY-D2189

IR 700DX IR 700DX NHS ester	Fluorescent Dyes
IR 700DX (IR 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IR 700DX binds to biomolecules. IR 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IR 700DX can be used as a highly flexible photosensitizer .

HY-DY1005

Hoechst 33342 trihydrochloride (solution)

Fluorescent Dyes

Hoechst 33342 trihydrochloride (solution) is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
Solvent and Concentration: Sterile water: 10 mg/mL

HY-W013967

1,6-Diphenylhexa-1,3,5-triene

Fluorescent Dyes

1,6-Diphenylhexa-1,3,5-triene is a membrane intercalator and hydrophobic fluorescent probe. 1,6-Diphenylhexa-1,3,5-triene intercalates into the non-polar region of lipid bilayers of adipocyte membranes with probe/membrane equilibrium affected by temperature, probe concentration, and membrane concentration. 1,6-Diphenylhexa-1,3,5-triene’s fluorescence intensity correlating with adipocyte membrane probe incorporation (Ex/Em = 350/452 nm) .

HY-15560

Hoechst 34580

5 Publications Verification

HOE 34580

Fluorescent Dyes

Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15560B

Hoechst 34580 tetrahydrochloride

5 Publications Verification

HOE 34580 tetrahydrochloride

Fluorescent Dyes

Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1359

Mito Red 1 Publications Verification	Fluorescent Dyes
Mito Red is a vital dye and mitochondrial stain that can be used to detect and evaluate mitochondrial function and status. Mito Red accumulates in mitochondria, and its fluorescence intensity is positively correlated with mitochondrial membrane potential. When the mitochondrial membrane potential increases, the fluorescence signal of Mito Red increases .

HY-D2868

DAPI

130+ Cited Publications

4',6-Diamidino-2-phenylindole

Fluorescent Dyes

DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

HY-D1631

Calcium Green-5N AM	Fluorescent Dyes
Calcium Green-5N AM is a Ca ²⁺-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-15627

Hoechst 33342 analog

5 Publications Verification

Fluorescent Dyes

Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15623

Hoechst 33258 analog

1 Publications Verification

Fluorescent Dyes

Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15619

Hoechst S 769121

Nuclear yellow

Fluorescent Dyes

Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1191

SYBR green I chloride

3 Publications Verification

Fluorescent Dyes

SYBR Green I chloride is a highly sensitive fluorescent nucleic acid dye that binds specifically to the minor groove of double-stranded DNA or intercalates between base pairs. SYBR Green I chloride exhibits weak fluorescence in the unbound state but emits bright fluorescence upon binding, and it preferentially binds to large-fragment DNA and DNA with high G+C content. SYBR Green I chloride is suitable for real-time PCR technology; its fluorescence intensity correlates with the amount and size of amplification products, enabling accurate quantification of gene expression and discrimination of amplicons via melting curve analysis without additional post-processing. SYBR Green I chloride is widely used in preclinical in vitro nucleic acid detection .

HY-15631

Hoechst 33258 analog 6

5+ Cited Publications

Fluorescent Dyes

Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution (Ex/Em = 356/451 nm) .

HY-D0916

Thiazole orange dimer YOYO 1 YOYO 1; YOYO1	Fluorescent Dyes
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).

HY-DY1034

4-MUNANA (solution)

Fluorescent Dyes

4-MUNANA (solution) is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .
Solvent and Concentration: Sterile water: 10 mM

HY-15630A

Hoechst 33342 analog 2 trihydrochloride

1 Publications Verification

Fluorescent Dyes

Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0110A

Fura-2 pentapotassium	Fluorescent Dyes
Fura-2 pentapotassium is a cell-impermeable scaled fluorescent dye that can be used for intracellular calcium imaging. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca ²⁺ level .

HY-D1556

18:1 PE CF

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium

Fluorescent Dyes

18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .

HY-15562

HOE 32021

Fluorescent Dyes

HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15561B

HOE-S 785026 trihydrochloride

meta-Hoechst trihydrochloride

Fluorescent Dyes

HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1631A

Calcium green-5N hexapotassium	Fluorescent Dyes
Calcium green-5N hexapotassium is a cell-impermeant Ca ²⁺-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-D2476

H2S Fluorescent probe 1	Fluorescent Dyes
H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe that detects hydrogen sulfide (H₂S) with almost no cytotoxicity. Upon the addition of increasing amounts of HS ^- to DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears gradually at 485 nm. H2S Fluorescent probe 1, the fluorescence intensity notes at 434 nm increasing rapidly by titration of HS ^- .

HY-D3010

VF dsDNA Green Dye

Fluorescent Dyes

VF dsDNA Green Dye is a fluorescent dye for detecting and quantifying double-stranded DNA (dsDNA). VF dsDNA Green Dye fluoresces only when bound to dsDNA, and the fluorescence intensity is proportional to the DNA concentration. VF dsDNA Green Dye does not fluoresce when bound to ssDNA, RNA, or free nucleotides. VF dsDNA Green Dye can detect dsDNA within the range of 25 pg/mL to 1000 ng/mL (Ex/Em = 480/520 nm).

HY-15629

HOE 32020

Fluorescent Dyes

HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15628

Hoechst 33258 analog 5

Fluorescent Dyes

Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15630

Hoechst 33342 analog 2

Fluorescent Dyes

Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1515

FM1-84 Neurodye GH1-84	Fluorescent Dyes
FM1-84 (Neurodye GH1-84) is a fluorescent dye. FM1-84 has lipophilic and facilitates association with membranes, resulting in an increase in fluorescence intensity (λ_ex=510 nm, λ_em=625 nm). FM1-84 can be used for synaptic vesicle recycling in neurons research .

HY-15626

ortho-iodoHoechst 33258

3 Publications Verification

Fluorescent Dyes

ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15622

meta-iodoHoechst 33258

Fluorescent Dyes

meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15561

HOE-S 785026

meta-Hoechst

Fluorescent Dyes

HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15632

para-iodoHoechst 33258

Fluorescent Dyes

para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15625

Hoechst 33258 analog 3

Fluorescent Dyes

Hoechst 33258 analog 3 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-15624

Hoechst 33258 analog 2

Fluorescent Dyes

Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D1769

N-hydroxy Rhodamine B amide	Fluorescent Dyes
N-hydroxy Rhodamine B amide is a ClO ^- indicator, which is hydrolyzed to prduce fluorescence in the presence of ClO ^-. The fluorescence intensity of N-hydroxy Rhodamine B amide is proportional to the product, thus can be used to quantify ClO ^-.

HY-D0038

BTBCT	Fluorescent Dyes
BTBCT is mainly used as a label in time-resolved fluorescence immunoassays (TRFIA). The lower limit of detection for TSH TR-IFMA is 0.011 mIU/L in a 10 μl sample volume. The high fluorescence intensity and stability of BTBCT improves the sensitivity of the assay .

HY-15563

HOE 33187

Fluorescent Dyes

HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D0151

Tetramethylrhodamine-5-maleimide	Fluorescent Dyes
Tetramethylrhodamine-5-maleimide is a fluorescent probe with high specificity for cysteine thiol (SH) groups. Tetramethylrhodamine-5-maleimide has high sensitivity, responds rapidly to negatively charged nanoparticles, and shows a concentration-dependent decrease in fluorescence intensity, but it is susceptible to interference from humic acids .

HY-D0110B

Fura-2 pentasodium	Fluorescent Dyes
Fura-2 pentasodium is a cell-impermeable scaled fluorescent dye that can be used for intracellular calcium imaging. Fura-2 pentasodium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca ²⁺ level .

HY-D2983

ARHB	Fluorescent Dyes
ARHB is a highly selective and sensitive NAT2 fluorescent probe suitable for real-time detection of NAT2 activity in various bacteria. ARHB can successfully penetrate the bacterial cells, and the fluorescence intensity is positively correlated with the expression level of NAT2. ARHB is used for high-throughput screening of natural inhibitors for tuberculosis .

HY-136784A

Rhod-2 sodium	Fluorescent Dyes
Rhod-2 sodium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 sodium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift .

Cat. No.	Product Name	Type

HY-D0856

Bis-Tris	Biochemical Assay Reagents
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

HY-NP008

β-Lactoglobulin

Biochemical Assay Reagents

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-B2235B

L-α-Lecithin (egg yolk, Type XVI-E), 99%

L-α-Phosphatidylcholine (egg yolk, Type XVI-E), 99%, lyophilized powder; 1,2-Diacyl-sn-glycero-3-phosphocholine (egg yolk, Type XVI-E), 99%; egg yolk Lecithins, Type XVI-E, 99%

Biochemical Assay Reagents

L-α-Lecithin (egg yolk, Type XVI-E), 99% (L-α-Phosphatidylcholine (egg yolk, Type XVI-E), 99%) is an active biomaterial. L-α-Lecithin (egg yolk, Type XVI-E), 99% forms liposomes with compounds (PF or BA). L-α-Lecithin (egg yolk, Type XVI-E), 99% increases membrane fluidity and affects microemulsion stability and fluorescence intensity stained with Nile red (HY-D0718). L-α-Lecithin (egg yolk, Type XVI-E), 99% It can be used for cell membrane structure research, biological membrane potential research, and liposome research .

HY-W250727

TNS sodium

1 Publications Verification

6-(p-Tolylamino)naphthalene-2-sulfonate sodium

Biochemical Assay Reagents

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-W105681

Bis-Tris hydrochloride	Biochemical Assay Reagents
Bis-Tris hydrochloride is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris hydrochloride can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

HY-W127781

Rhod-2 triammonium	Biochemical Assay Reagents
Rhod-2 triammonium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 triammonium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift .

HY-D0157

ZnAF-2	Biochemical Assay Reagents
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-D0856R

Bis-Tris (Standard)

Biochemical Assay Reagents

Bis-Tris (Standard) is the analytical standard of Bis-Tris. This product is intended for research and analytical applications. Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

Cat. No.	Product Name	Target	Research Area

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P11114

Periplanetasin-4	Bacterial p38 MAPK Reactive Oxygen Species (ROS) Apoptosis Caspase	Infection Inflammation/Immunology
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis .

HY-P4900

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Others
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .

HY-P2089

Dnp-PYAYWMR	MMP	Others
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .

HY-P4919

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-P5415

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS	HIV	Others
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-K_d protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)

Cat. No.	Product Name

HY-K1047

AntiFade Mounting Medium (with DAPI) 10+ Cited Publications
Anti-Fade Mounting Medium (with DAPI) is a mounting reagent designed to retard fluorescence photobleaching and preserve signal intensity during long-term imaging. For immediate observation of samples, please select HY-K1048, a non-solidifying anti-fade mounting medium with DAPI. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Chemical Structure

HY-D0856S1

Bis-Tris-d14

Bis-Tris-d₁₄ is the deuterium labeled Bis-Tris (HY-D0856). Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

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