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gluconeogenesis

" in MedChemExpress (MCE) Product Catalog:

95

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8

Biochemical Assay Reagents

3

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36

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5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0511
    Biotin
    Maximum Cited Publications
    26 Publications Verification

    Vitamin B7; Vitamin H; D-Biotin

    		 Environmental Pollutants Endogenous Metabolite Metabolic Disease
    Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin
  • HY-P0082
    Glucagon (1-29), bovine, human
    10+ Cited Publications

    Glucagon

    		 GCGR Metabolic Disease Cancer
    Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis . Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation .
    Glucagon (1-29), bovine, human
  • HY-W008807
    Phosphoenolpyruvic acid potassium
    1 Publications Verification

    Phosphoenolpyruvate potassium

    		 Endogenous Metabolite Metabolic Disease
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) potassium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid potassium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid potassium also exhibits cytoprotective and anti-oxidative properties .
    Phosphoenolpyruvic acid potassium
  • HY-N0143
    Phlorizin
    10+ Cited Publications

    Floridzin

    		 Caspase JAK GLUT STAT Apoptosis Bacterial SGLT mTOR Akt NF-κB PI3K DNA/RNA Synthesis Infection Neurological Disease Metabolic Disease Cancer
    Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities .
    Phlorizin
  • HY-137808
    Succinyl-Coenzyme A sodium
    3 Publications Verification

    Succinyl-CoA sodium

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
    Succinyl-Coenzyme A sodium
  • HY-151223
    D-Glyceraldehyde 3-phosphate
    1 Publications Verification

    Triose phosphate

    		 Endogenous Metabolite Biochemical Assay Reagents Metabolic Disease
    D-Glyceraldehyde 3-phosphate (Triose phosphate) is a common molecule in living organisms and is an important intermediate in glycolysis and gluconeogenesis, as well as a sugar product of the Calvin cycle. D-Glyceraldehyde 3-phosphate is involved in the biosynthesis of tryptophan and thiamin. D-Glyceraldehyde 3-phosphate is released as aldehyde by aldolase or triose phosphate isomerase. D-Glyceraldehyde 3-phosphate forms adducts with thiols .
    D-Glyceraldehyde 3-phosphate
  • HY-W010382
    Oxaloacetic acid
    2 Publications Verification

    2-Oxosuccinic acid

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Metabolic Disease
    Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .
    Oxaloacetic acid
  • HY-128748
    DL-Glyceraldehyde

    		Endogenous Metabolite Others
    DL-Glyceraldehyde is a bioactive substance involved in cellular energy metabolism and a key intermediate in sugar metabolism pathways (such as glycolysis and gluconeogenesis). During glycolysis, DL-Glyceraldehyde is converted by enzymes into other metabolites to provide energy for cells; during gluconeogenesis, DL-Glyceraldehyde participates in the synthesis of glucose as a precursor. In the field of medical research, DL-Glyceraldehyde can be used to study diseases related to sugar metabolism, such as diabetes, tumors, etc[1][2].
    DL-Glyceraldehyde
  • HY-134816
    D-Glucan

    		Toll-like Receptor (TLR) Metabolic Disease Inflammation/Immunology Cancer
    D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) .
    D-Glucan
  • HY-P0082A
    Glucagon (1-29), bovine, human hydrochloride
    10+ Cited Publications

    Glucagon hydrochloride

    		 GCGR Metabolic Disease Cancer
    Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis . Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation .
    Glucagon (1-29), bovine, human hydrochloride
  • HY-113054
    DL-Glyceraldehyde 3-phosphate

    		Acyltransferase Bacterial Endogenous Metabolite Infection Metabolic Disease
    DL-Glyceraldehyde 3-phosphate is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. DL-Glyceraldehyde 3-phosphate is a potent inhibitor of the growth of E. coli. DL-Glyceraldehyde 3-phosphate is a competitive inhibitor of the acyltransferase .
    DL-Glyceraldehyde 3-phosphate
  • HY-113126
    3-Hydroxyisobutyric acid

    		Endogenous Metabolite ATP Synthase Neurological Disease Metabolic Disease
    3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .
    3-Hydroxyisobutyric acid
  • HY-108743
    Insulin degludec

    		Insulin Receptor Endocrinology
    Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes .
    Insulin degludec
  • HY-108468
    KL001
    2 Publications Verification

    		 Cryptochrome Metabolic Disease
    KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .
    KL001
  • HY-P2917
    Glycerol kinase, microorganism

    GyK

    		 Nuclear Hormone Receptor 4A/NR4A Metabolic Disease Inflammation/Immunology
    Glycerol kinase, microorganism (GyK) acts as a NR4A1 inhibitor with enzymatic activity. It directly binds to and inhibits the transcription factor NR4A1, thereby negatively regulating hepatic gluconeogenesis and reducing blood glucose levels. Glycerol kinase, microorganism positively regulates UCP1 expression via partial dependence on the β-adrenergic receptor-cAMP-CREB pathway, promotes browning of white adipose tissue and thermogenesis, and further modulates intracellular fatty acid composition and energy metabolism. In diabetic mouse models, overexpression of Glycerol kinase effectively antagonizes NR4A1-induced hyperglycemia, demonstrating potential for improving glucose homeostasis. Glycerol kinase, microorganism can be used for studies on diabetes and obesity .
    Glycerol kinase, microorganism
  • HY-B0528A
    Octopamine hydrochloride
    5 Publications Verification

    (±)-p-Octopamine hydrochloride

    		 Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine hydrochloride
  • HY-14414
    GSK4112
    10+ Cited Publications

    SR6452

    		 REV-ERB Apoptosis Metabolic Disease
    GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways .
    GSK4112
  • HY-W587427
    D-2-Phosphoglyceric acid trisodium

    		Endogenous Metabolite Monocarboxylate Transporter Neurological Disease Cancer
    D-2-Phosphoglyceric acid trisodium is a glycolysis and gluconeogenesis intermediate with altered levels linked to MCT4-modulated glycolytic pathways. D-2-Phosphoglyceric acid trisodium shows reduced intracellular levels in hypoxic glioblastoma stem cells after MCT4 knockdown. D-2-Phosphoglyceric acid trisodium can be used for the research of glioblastoma .
    D-2-Phosphoglyceric acid trisodium
  • HY-136717
    FBPase-1 inhibitor-1

    		FBPase Metabolic Disease
    FBPase-1 inhibitor-1 (Compound 1) is an allosteric FBPase-1 inhibitor with an IC50 of 3.3 μM or 3.9 μM. FBPase-1 inhibitor-1 blocks gluconeogenesis by inhibiting FBPase-1. FBPase-1 inhibitor-1 can be used for the research of type 2 diabetes (t2dm) .
    FBPase-1 inhibitor-1
  • HY-16307
    MB05032
    5+ Cited Publications

    		 FBPase Metabolic Disease
    MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
    MB05032
  • HY-W039315
    2,5-Anhydro-D-mannitol, 97%

    		Biochemical Assay Reagents Metabolic Disease
    2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .
    2,5-Anhydro-D-mannitol, 97%
  • HY-N5083
    Saponarin
    1 Publications Verification

    		 PERK NF-κB p38 MAPK AMPK Interleukin Related COX Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .
    Saponarin
  • HY-B2099A
    Buformin hydrochloride
    3 Publications Verification

    1-Butylbiguanide hydrochloride

    		 AMPK Cancer
    Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .
    Buformin hydrochloride
  • HY-Y0624
    4-Pentenoic acid

    		Endogenous Metabolite Mitochondrial Metabolism Metabolic Disease
    4-Pentenoic acid is a medium-chain unsaturated fatty acid. 4-Pentenoic acid has hypoglycemic and fatty acid oxidation inhibitory activities. 4-Pentenoic acid can affect blood glucose metabolism and energy metabolism through mechanisms such as inhibiting long-chain fatty acid oxidation, reducing gluconeogenesis, and promoting glucose utilization .
    4-Pentenoic acid
  • HY-P2726
    Aldolase, Rabbit muscle

    Fructose-diphosphate aldolase

    		 Fructose-1,6-bisphosphate aldolase Endogenous Metabolite Metabolic Disease
    Aldolase, Rabbit muscle (Fructose-diphosphate aldolase) is a glycolytic enzyme and glucose availability sensor. Aldolase, Rabbit muscle catalyzes the reversible carbon-carbon cleavage of fructose-1,6-bisphosphate to produce dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, Rabbit muscle is an essential component for v-ATPase activity. Aldolase, Rabbit muscle participates in processes such as gluconeogenesis, the Calvin cycle and glycolysis .
    Aldolase, Rabbit muscle
  • HY-113049
    Phosphoenolpyruvic acid

    Phosphoenolpyruvate

    		 Endogenous Metabolite Metabolic Disease
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid also exhibits cytoprotective and anti-oxidative properties .
    Phosphoenolpyruvic acid
  • HY-W009417
    Cedryl acetate

    		Environmental Pollutants Glycosidase Metabolic Disease
    Cedryl acetate is an orally active α-glucosidase inhibitor with an IC50 of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome .
    Cedryl acetate
  • HY-W134005
    Mg(Ⅱ)-EDTA disodium tetrahydrate

    Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate

    		 Phosphatase Others
    Mg(Ⅱ)-EDTA disodium tetrahydrate is a reversible non-covalent activator of fructose diphosphatase (Km=0.9 μM). Mg(Ⅱ)-EDTA disodium tetrahydrate synergistically activates fructose diphosphatase with free Mg 2+, promotes the hydrolysis of fructose-1,6-bisphosphate at pH≤8, and plays a role in enhancing the activity of key enzymes in gluconeogenesis .
    Mg(Ⅱ)-EDTA disodium tetrahydrate
  • HY-N7676
    Marein
    3 Publications Verification

    		 AMPK HDAC Cardiovascular Disease Neurological Disease Metabolic Disease
    Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .
    Marein
  • HY-P2989
    Pyruvate carboxylase

    		Endogenous Metabolite Metabolic Disease Cancer
    Pyruvate carboxylase is a key mitochondrial anaplerotic enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Pyruvate carboxylase not only maintains tricarboxylic acid cycle activity and redox homeostasis, but also drives hepatic gluconeogenesis and fatty acid synthesis. The activity of Pyruvate carboxylase is upregulated in insulin-resistant states, exacerbating hepatic glucose production. Pyruvate carboxylase also shows significantly enhanced expression in early-stage non-small cell lung cancer (NSCLC). Pyruvate carboxylase promotes tumor proliferation by supporting nucleotide and lipid synthesis, and its functional deficiency cannot be compensated by glutaminolysis. Pyruvate carboxylase can be used in the research of prediabetes type 2 and NSCLC .
    Pyruvate carboxylase
  • HY-B0511R
    Biotin (Standard)

    Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)

    		 Endogenous Metabolite Reference Standards Metabolic Disease
    Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin (Standard)
  • HY-34154
    4-(Dimethylamino)phenol

    		Lactate Dehydrogenase Others
    4-(Dimethylamino)phenol is a potent cyanide antidote. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH. 4-(Dimethylamino)phenol’s toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function .
    4-(Dimethylamino)phenol
  • HY-148285
    Succinyl CoA

    Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A

    		 Endogenous Metabolite Metabolic Disease
    Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
    Succinyl CoA
  • HY-W010382S
    Oxaloacetic acid-13C4
    1 Publications Verification

    2-Oxosuccinic acid-13C4

    		 Endogenous Metabolite Isotope-Labeled Compounds Metabolic Disease
    Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis .
    Oxaloacetic acid-13C4
  • HY-147645
    FBPase-IN-2

    		FBPase Metabolic Disease
    FBPase-IN-2 (Compound HS36) is a covalent FBPase inhibitor with an IC50 value of 0.15 μM for wild-type FBPase. FBPase-IN-2 inhibits glucose production in primary mouse hepatocytes via gluconeogenesis modulation. FBPase-IN-2 can be used for the research of type 2 diabetes mellitus .
    FBPase-IN-2
  • HY-W008807S
    Phosphoenolpyruvic acid potassium-13C2

    Phosphoenolpyruvate potassium-13C2

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Phosphoenolpyruvic acid (potassium)- 13C2 is the 13C labeled Phosphoenolpyruvic acid potassium (HY-W008807) . Phosphoenolpyruvic acid (Phosphoenolpyruvate) potassium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid potassium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid potassium also exhibits cytoprotective and anti-oxidative properties .
    Phosphoenolpyruvic acid potassium-13C2
  • HY-B0511S3
    Biotin-13C5

    Vitamin B7-13C5; Vitamin H-13C5; D-Biotin-13C5

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin-13C5
  • HY-W115752
    Hydrazine sulfate (99%)

    Diamine sulfate (99%)

    		 PEPCK Aldehyde Dehydrogenase (ALDH) Neurological Disease Metabolic Disease Cancer
    Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP + toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease .
    Hydrazine sulfate (99%)
  • HY-149987
    LY3522348

    KHK-IN-3

    		 Ketohexokinase Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
    LY3522348
  • HY-P2820
    Phosphoglucomutase, Rabbit muscle

    		Endogenous Metabolite Metabolic Disease
    Phosphoglucomutase, Rabbit muscle is often used in biochemical studies. Phosphoglucomutase is an enzyme that can transfer the phosphate group on the α-D-glucose monomer forward from the 1-position to the 6-position or reversely transfer from the 6-position to the 1-position, and promote the glucose-1-phosphate and glucose-6-phosphate Transform each other. Phosphoglucomutase is a key enzyme in glycolysis and gluconeogenesis, and plays an important role in the metabolism of proteins, lipids and nucleic acids .
    Phosphoglucomutase, Rabbit muscle
  • HY-N0143A
    Phlorizin dihydrate
    10+ Cited Publications

    Floridzin dihydrate

    		 SGLT PI3K Akt GLUT NF-κB JAK STAT Caspase Apoptosis DNA/RNA Synthesis mTOR Bacterial Infection Neurological Disease Metabolic Disease Cancer
    Phlorizin (Floridzin) dihydrate is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin dihydrate promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin dihydrate reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin dihydrate induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin dihydrate also exhibits antibacterial, anti-inflammatory and neuroprotective activities .
    Phlorizin dihydrate
  • HY-W010382R
    Oxaloacetic acid (Standard)
    2 Publications Verification

    2-Oxosuccinic acid (Standard)

    		 Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) Metabolic Disease
    Oxaloacetic acid (Standard) is the analytical standard of Oxaloacetic acid. This product is intended for research and analytical applications. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .
    Oxaloacetic acid (Standard)
  • HY-N3720
    Demethoxycapillarisin

    6-Demethoxycapillarisin

    		 PEPCK Metabolic Disease
    Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC50: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production .
    Demethoxycapillarisin
  • HY-W011704
    Phosphoenolpyruvic acid cyclohexylammoniu​m salt
    1 Publications Verification

    Phosphoenolpyruvate cyclohexylammoniu​m salt

    		 Endogenous Metabolite Metabolic Disease
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) cyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid cyclohexylammonium salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid cyclohexylammonium salt also exhibits cytoprotective and anti-oxidative properties .
    Phosphoenolpyruvic acid cyclohexylammoniu​m salt
  • HY-N7092A
    L-(+)-Fructose, 95%

    L-arabino-2-Hexulose, 95%

    		 Endogenous Metabolite Metabolic Disease
    L-(+)-Fructose, 95% (L-arabino-2-Hexulose, 95%) is the L-isomer of D-Fructose (HY-N7092). L-(+)-Fructose, 95% participates in glycolysis and gluconeogenesis, and can be used to study photosynthesis and carbohydrate storage in plant biology. L-(+)-Fructose, 95% is applicable for investigating the activity of fructokinase and other fructose-metabolizing enzymes .
    L-(+)-Fructose, 95%
  • HY-B0528AR
    Octopamine hydrochloride (Standard)

    (±)-p-Octopamine hydrochloride (Standard)

    		 Reference Standards Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine hydrochloride (Standard)
  • HY-P2822
    Phosphoglycerate kinase, yeast

    PGK

    		 Endogenous Metabolite Infection Endocrinology Cancer
    Phosphoglycerate kinase, yeast (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes .
    Phosphoglycerate kinase, yeast
  • HY-168103
    FBPase-IN-3

    		FBPase Metabolic Disease
    FBPase-IN-3 (compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with an IC50 of 2.08 μM. FBPase-IN-3 exhibits potent inhibitory activity of gluconeogenesis .
    FBPase-IN-3
  • HY-W197205
    SL010110

    		Sirtuin Histone Acetyltransferase PEPCK Metabolic Disease
    SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research .
    SL010110
  • HY-W011704A
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt
    1 Publications Verification

    Phosphoenolpyruvate tricyclohexylammoniu​m salt

    		 Endogenous Metabolite Metabolic Disease
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) tricyclohexylammoniu​m salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt also exhibits cytoprotective and anti-oxidative properties .
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt

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