Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
halflives
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "halflives" in MCE Product Catalog:
Target:
Research Areas:
GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM, and an EC50 value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma .
Cat. No.: HY-175207
CAS No.: 3109469-27-1
Target:
Research Areas:
CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM .
CDK9-IN-13 (compound 38) is potent and selective CDK9 inhibitor, with an IC50 of <3 nM. CDK9-IN-13 exhibits short half-lives in rodents .
Cat. No.: HY-128268
CAS No.: 735303-62-5
PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively .
Cat. No.: HY-148177
CAS No.: 1821293-40-6
Synonyms: ZY-19489; MMV 253; AZ13721412
Sutidiazine (ZY-19489) is an orally active and antimalarial agent. Sutidiazine inhibits parasitemia-induced infection. Sutidiazine shows short half-lives (approximately 7 h) and an exposure effect .
Cat. No.: HY-W040303
CAS No.: 98967-40-9
Synonyms: DE-498; XRD-498
Target:
Research Areas:
Flumetsulam is pre- and postemergence herbicide, which is susceptible to dissipate in corn ecosystem with half-live less than 8.7 days .
Cat. No.: HY-W040303R
CAS No.: 98967-40-9
Synonyms: DE-498 (Standard); XRD-498 (Standard)
Target:
Research Areas:
Flumetsulam (Standard) is the analytical standard of Flumetsulam. This product is intended for research and analytical applications. Flumetsulam is pre- and postemergence herbicide, which is susceptible to dissipate in corn ecosystem with half-live less than 8.7 days .
Cat. No.: HY-164815
CAS No.: 104732-22-1
Synonyms: Tianeptine metabolite MC5
Target:
Research Areas:
S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants .
Cat. No.: HY-123639
CAS No.: 261766-32-9
Synonyms: N-(2-Phenylethyl)-indomethacin amide
Target:
Research Areas:
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively .
Cat. No.: HY-166341S
CAS No.: 1330822-91-7
Synonyms: Tianeptine metabolite MC5-d4
Cat. No.: HY-147740
CAS No.: 70492-21-6
Target:
Research Areas:
WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkhalf-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
