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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
heat shock protein 90-alpha
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "heat shock protein 90-alpha" in MCE Product Catalog:
Cat. No.: HY-149431
Target:
Research Areas:
NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins .
Cat. No.: HY-149432
Target:
Research Areas:
NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC50: 0.51 μM). NDNA3 is a permanently charged analog with low membrane permeability and low toxicity to Ovcar-8 (IC50: 12.66 μM) and MCF-10A (IC50: 11.72 μM) cells. NDNA3 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins .
Cat. No.: HY-155064
CAS No.: 3031102-92-5
Target:
Research Areas:
TRAP1-IN-2 is a TRAP1-selective inhibitor, with a Kd value of 0.04 μM against human TRAP1. TRAP1-IN-2 exhibits more than 250-fold selectivity for Grp94 and shows no detectable affinity for cytosolic Hsp90α/β. TRAP1-IN-2 selectively induces the degradation of TRAP1 client proteins by inhibiting its ATPase activity, without triggering the heat shock response or affecting cytosolic Hsp90 client proteins. TRAP1-IN-2 suppresses oxidative phosphorylation, shifts cellular metabolism toward glycolysis, disrupts the stability of the TRAP1 tetramer and the mitochondrial membrane potential. TRAP1-IN-2 can be used in studies related to prostate cancer, cervical cancer, and ovarian cancer .
Cat. No.: HY-P80714
Synonyms: HSP90AA1; HSP90A; HSPC1; HSPCA; heat shock protein HSP 90-alpha; heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; heat shock protein HSP 90-beta; HSP 90; heat shock 84 kDa; HSP 84; HSP84
Cat. No.: HY-P80714A
Synonyms: HSP90AA1; HSP90A; HSPC1; HSPCA; heat shock protein HSP 90-alpha; heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; heat shock protein HSP 90-beta; HSP 90; heat shock 84 kDa; HSP 84; HSP84
Cat. No.: HY-P703083
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; heat shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; Hsp89; LAP-2; Hsp90; heat shock protein 90kDa alpha Family Class A Member 1; heat shock protein 90kDa alpha (Cytosolic), Class A Member 1; heat shock 90kD protein 1, alpha-Like 4; Epididymis Secretory Sperm Binding protein Li 65p; heat shock 90kD protein, alpha-Like 4; Epididymis Luminal Secretory protein 52; HSP90AA1 protein; Lipopolysaccharide-Associated protein 2; HSPCAL1; heat shock protein Family C Member 1; HSP89A; heat shock 90kDa protein 1, alpha; Hsp103; Renal Carcinoma Antigen NY-REN-38; EL52; heat shock 90kD protein 1, alpha; HSPN; heat shock protein HSP 90-alpha; LAP2; LPS-Associated protein 2; heat shock protein 90 alpha Family Class A Member 1; HEL-S-65p
Species:
Human
Source:
E. coli
Cat. No.: HY-P706229
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; heat shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; Hsp89; LAP-2; Hsp90; heat shock protein 90kDa alpha Family Class A Member 1; heat shock protein 90kDa alpha (Cytosolic), Class A Member 1; heat shock 90kD protein 1, alpha-Like 4; Epididymis Secretory Sperm Binding protein Li 65p; heat shock 90kD protein, alpha-Like 4; Epididymis Luminal Secretory protein 52; HSP90AA1 protein; Lipopolysaccharide-Associated protein 2; HSPCAL1; heat shock protein Family C Member 1; HSP89A; heat shock 90kDa protein 1, alpha; Hsp103; Renal Carcinoma Antigen NY-REN-38; EL52; heat shock 90kD protein 1, alpha; HSPN; heat shock protein HSP 90-alpha; LAP2; LPS-Associated protein 2; heat shock protein 90 alpha Family Class A Member 1; HEL-S-65p
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
