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herbicide metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Herbicide (9) Acetolactate Synthase (ALS) (1) Apoptosis (1) Caspase (1) Cytochrome P450 (8) Environmental Pollutants (4) Estrogen Receptor/ERR (2) Fungal (1) FXR (2) Glutathione S-transferase (3) Interleukin Related (1) Isotope-Labeled Compounds (3) MDM-2/p53 (1) Pregnane X Receptor (PXR) (2) Reactive Oxygen Species (ROS) (5) Reference Standards (5) SHMT (1) SOD (1)
By Research Areas:	Cancer (1) Metabolic Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Herbicide Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0859

MCPA 1 Publications Verification	Environmental Pollutants Cytochrome P450 Herbicide	Metabolic Disease
MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-12853

Mesotrione 2 Publications Verification	Environmental Pollutants Reactive Oxygen Species (ROS)	Others
Mesotrione is a *herbicide* belongs to the benzoylcyclohexanedione family. Mesotrione is a potent and competitive and reversible inhibitor of HPPD enzyme. Mesotrione is selective to maize due to rapid metabolism and relative high tolerance by the susceptible crop plant .

HY-144900

Topramezone	Environmental Pollutants Reactive Oxygen Species (ROS)	Others
Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-W020788

Benoxacor CGA 154281	Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Metabolic Disease Cancer
Benoxacor (CGA 154281) is a herbicide safener and *xenobiotic metabolism* regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase**). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-B2035

Pretilachlor	Herbicide Caspase Cytochrome P450 MDM-2/p53 Interleukin Related Reactive Oxygen Species (ROS) Apoptosis	Others
Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .

HY-170920

Herbicide safener-4	Cytochrome P450 SOD Glutathione S-transferase Acetolactate Synthase (ALS)	Others
Herbicide safener-4 (Compound I-15) is a Herbicide safener, improving the herbicide resistance of crops without reducing the herbicidal effect on targeted weed species. Herbicide safener-4 competitively binds to the ALS active site with Mesosulfuron-methyl (HY-126987). Herbicide safener-4 enhances GSH (HY-D0187), GST, CYP450, POD, SOD and ALS activity in plants .

HY-162883

SHMT-IN-4	SHMT	Others
SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC₅₀ value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees .

HY-B0859S1

MCPA-d3	Isotope-Labeled Compounds Herbicide Cytochrome P450	Metabolic Disease
MCPA-d₃ is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-144900R

Topramezone (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Others
Topramezone (Standard) is the analytical standard of Topramezone. This product is intended for research and analytical applications. Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-W020788R

Benoxacor (Standard) CGA 154281 (Standard)	Reference Standards Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Others
Benoxacor (Standard) is the analytical standard of Benoxacor. This product is intended for research and analytical applications. Benoxacor (CGA 154281) is a herbicide safener and *xenobiotic metabolism* regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase**). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-12853R

Mesotrione (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Others
Mesotrione (Standard) is the analytical standard of Mesotrione. This product is intended for research and analytical applications. Mesotrione is a herbicide belongs to the benzoylcyclohexanedione family. Mesotrione is a potent and competitive and reversible inhibitor of HPPD enzyme. Mesotrione is selective to maize due to rapid metabolism and relative high tolerance by the susceptible crop plant .

HY-W713900

MCPA-d3-1	Isotope-Labeled Compounds Herbicide Cytochrome P450	Metabolic Disease
MCPA-d₃-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-B0859R

MCPA (Standard)	Herbicide Reference Standards Cytochrome P450	Metabolic Disease
MCPA (Standard) is the analytical standard of MCPA (HY-B0859). This product is intended for research and analytical applications. MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-B0859S

MCPA-13C8 4-Chloro-2-Methylphenoxyacetic acid-¹³C₈	Isotope-Labeled Compounds Herbicide Cytochrome P450	Metabolic Disease
MCPA- ¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-B2035R

Pretilachlor (Standard)	Herbicide Reference Standards	Others
Pretilachlor (Standard) is the analytical standard of Pretilachlor (HY-B2035). This product is intended for research and analytical applications. Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .

HY-N12990

Myrigalone A MyA	Herbicide Fungal	Others
Myrigalone A (MyA) is a plant ethylene biosynthesis inhibitor and natural *herbicide* . Myrigalone A possesses antioxidant, antifungal, and antimicrobial activities. Myrigalone A interferes with auxin homeostasis during seed germination. Myrigalone A delays seed germination, inhibits the formation of roots, hypocotyls, and root hairs, and causes developmental delay in specific organisms. Myrigalone A triggers the induction of detoxification programs, alters the metabolism of gibberellins, cis-(+)-12-oxophytodienoic acid, and jasmonic acid, disrupts the antioxidant system and oxidative signaling, and impairs the function of aquaporins and water uptake in imbibed seeds. Myrigalone A can be used in studies related to herbicides and plant growth regulators .

HY-B0859A

MCPA sodium 1 Publications Verification	Herbicide Cytochrome P450	Metabolic Disease
MCPA sodium is an orally active phenoxyacetic acid *herbicide. MCPA sodium interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA sodium increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA sodium can be used to control broadleaf weeds .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12990

Myrigalone A MyA	Structural Classification Flavonoids Ketones, Aldehydes, Acids Plants Dihydrochalcones Myrica gale L. Source Classification Myricaceae	Herbicide Fungal
Myrigalone A (MyA) is a plant ethylene biosynthesis inhibitor and natural *herbicide* . Myrigalone A possesses antioxidant, antifungal, and antimicrobial activities. Myrigalone A interferes with auxin homeostasis during seed germination. Myrigalone A delays seed germination, inhibits the formation of roots, hypocotyls, and root hairs, and causes developmental delay in specific organisms. Myrigalone A triggers the induction of detoxification programs, alters the metabolism of gibberellins, cis-(+)-12-oxophytodienoic acid, and jasmonic acid, disrupts the antioxidant system and oxidative signaling, and impairs the function of aquaporins and water uptake in imbibed seeds. Myrigalone A can be used in studies related to herbicides and plant growth regulators .

Cat. No.	Product Name	Chemical Structure

HY-B0859S1

MCPA-d3
MCPA-d₃ is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

MCPA-d3

MCPA-d₃ is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-W713900

MCPA-d3-1
MCPA-d₃-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

MCPA-d3-1

MCPA-d₃-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

HY-B0859S

MCPA-13C8
MCPA- ¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid *herbicide. MCPA interferes with membrane integrity, energy metabolism* (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

MCPA-13C8

MCPA- ¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .

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