HPPD-IN-13
HPPD-IN-13 is a potent herbicide targeting HPPD, with an IC50 value of 0.132 μM against EcHPPD. HPPD-IN-13 primarily forms bidentate coordination with the ferrous ion in the active site of HPPD, and competitively blocks HPPA metabolism via π-π stacking and multiple hydrogen bonds, ultimately leading to plant albinism and death. HPPD-IN-13 can be used in the research and development of novel bleaching herbicides.
For research use only. We do not sell to patients.
- Formula: C15H11NO3
- Molecular Weight:253.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
EcHPPD 0.132 μM (IC50) |
In Vitro
HPPD-IN-13 (compound III-2) potently inhibits Echinochloa crus-galli HPPD with an IC50 of 0.132 μM[1].
HPPD-IN-13 binds stably to Arabidopsis thaliana HPPD through bidentate coordination with Co2+, π-π stacking interactions, and multiple hydrogen bonds, thereby contributing to its potent inhibitory activity[1].
HPPD-IN-13 (active ingredient: 150 g/ha) inhibits the growth of Echinochloa crus-galli (99%-90%), Setaria viridis (89%-70%), Lolium perenne (89%-70%), Lolium multiflorum (99%-90%), and Abutilon theophrasti (99%-90%) in post-emergence herbicide assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 253.25
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Formula C15H11NO3
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SMILES
O=C(/C(C#N)=C(C1CC1)\O)C2=CC3=C(O2)C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPPD-IN-13 Related Classifications
HY-189010 Related Classifications
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