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Results for "

hm5

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Click Chemistry

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106432A
    Sabcomeline hydrochloride

    SB-202026 hydrochloride; Memric hydrochloride

    		 mAChR Dopamine Receptor Neurological Disease
    Sabcomeline (SB-202026; Memric) hydrochloride is a muscarinic receptor agonist capable of crossing the blood-brain barrier. Sabcomeline hydrochloride exhibits affinity for all hM1 to hM5 subtypes (pKi=6.72-7.23), and shows near-full agonism at the hM3 receptor, inducing extracellular acidification. Sabcomeline hydrochloride alters the binding kinetics of dopamine D2 receptors through neural network regulation. Sabcomeline hydrochloride also causes minimal cardiovascular changes, effectively reverses spatial memory deficits in rodents and induces conditioned taste aversion. Sabcomeline hydrochloride is an important tool compound in studies of Alzheimer's disease and related neurodegenerative diseases .
    Sabcomeline hydrochloride
  • HY-12567A
    (R)-ML375

    (R)-VU0483253

    		 Drug Isomer Others
    (R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 (HY-12567). (R)-ML375 is devoid of M5 mAChR activity (hM5, IC50>30 μM) .
    (R)-ML375
  • HY-RS02664
    CHRM5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CHRM5 Human Pre-designed siRNA Set A contains three designed siRNAs for CHRM5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CHRM5 Human Pre-designed siRNA Set A
    CHRM5 Human Pre-designed siRNA Set A
  • HY-183853
    Arecaidine-propargyl ester

    		mAChR Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis SOD Sirtuin Cardiovascular Disease Neurological Disease Cancer
    Arecaidine-propargyl ester is a selective M2 muscarinic receptor agonist with blood-brain barrier permeability, with a pKi of 5.91 for hm1, 7.06 for hm2, 6.07 for hm3, 6.01 for hm4, and 6.03 for hm5. Arecaidine-propargyl ester stimulates central and peripheral muscarinic receptors. Arecaidine-propargyl ester increases intracellular ROS, induces DNA damage and Apoptosis, and upregulates the expression of MnSOD and SIRT1. Arecaidine-propargyl ester reduces sympathetic nerve outflow, induces dose-dependent hypotension, and triggers negative chronotropic effects at high peripheral doses. Arecaidine-propargyl ester can be used in research related to Alzheimer's disease and glioblastoma .
    Arecaidine-propargyl ester
  • HY-W751672
    2′-O-Methyl-5-hydromethylcytidine

    hm5Cm

    		 Nucleoside Antimetabolite/Analog Others
    2′-O-Methyl-5-hydromethylcytidine (hm5Cm) is a 5-hydroxymethylcytidine (HY-152854) derivative. 2′-O-Methyl-5-hydromethylcytidine has also been detected in tRNA .
    2′-O-Methyl-5-hydromethylcytidine

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