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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
human DNA polymerase β
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "human DNA polymerase β" in MCE Product Catalog:
Cat. No.: HY-137697D
Purity: ≥98.0%
Research Areas:
ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
Cat. No.: HY-50735
CAS No.: 69123-90-6
Synonyms: NSC 382097; FIAC; FOAC
Target:
Research Areas:
Fiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of HSV DNA polymerase, with a Ki of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections .
Cat. No.: HY-137697
CAS No.: 66004-77-1
Cat. No.: HY-N9454
CAS No.: 91893-83-3
Cat. No.: HY-120105
CAS No.: 170747-33-8
Research Areas:
NSC666715 is a DNA polymerase β (Pol-β) inhibitor. NSC666715 directly and specifically interacts with Pol-β, interferes with its binding to damaged DNA, blocks its dRP lyase activity, and inhibits Pol-β-mediated SN- and LP-BER. NSC666715 induces AP site accumulation and S-phase cell cycle arrest, and triggers senescence and apoptosis (apoptosis) via the p53/p21 pathway in colorectal cancer cells. NSC666715 enhances TMZ (HY-17364)-induced DNA damage, senescence and apoptosis, and potentiates the cytotoxicity of TMZ. NSC666715 inhibits tumor growth in colon cancer xenograft models. NSC666715 can be used in research related to colorectal cancer .
Cat. No.: HY-137697B
CAS No.: 93939-77-6
Research Areas:
ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
Cat. No.: HY-19869
CAS No.: 878670-89-4
Target:
Research Areas:
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS .
Cat. No.: HY-P7883
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: POLB; 5'-DRP Lyase; DNA polymerase Beta; AP Lyase; polymerase (DNA Directed), Beta; DNA polymerase Beta Subunit; 5'-Deoxyribose-Phosphate Lyase; DNA polymerase; polymerase (DNA) Beta; DNA Pol Beta
Species:
Human
Source:
E. coli
Cat. No.: HY-182552
CAS No.: 65025-62-9
Cat. No.: HY-186293
CAS No.: 662144-62-9
Research Areas:
3-Lauroylcatechin is a DPPH free radical scavenger. 3-Lauroylcatechin inhibits the activities of mammalian DNA polymerase α and β. 3-Lauroylcatechin can be used in studies related to colon cancer .
Cat. No.: HY-N21920
CAS No.: 796062-77-6
Category:
Target:
Cat. No.: HY-N21925
CAS No.: 18449-25-7
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
