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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
human DNA polymerase-
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "human DNA polymerase-" in MCE Product Catalog:
17
17 Publications Verification
Cat. No.: HY-N6733
CAS No.: 38966-21-1
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Elsulfavirine (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .
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1 Cited Publications
Cat. No.: HY-117664
CAS No.: 1633660-76-0
Target:
Research Areas:
PNR-7-02 is a dual Rev1 and human DNA polymerase η (hpol η) inhibitor, with an IC50 value of 8 μM against hpol η. PNR-7-02 binds to hpol η to disrupt the orientation of template DNA and block the catalytic function of hpol η. When used in combination with Cisplatin (HY-17394), PNR-7-02 induces DNA damage and replication stress in cells with intact hpol η function. PNR-7-02 can be used in mechanism studies related to chronic myeloid leukemia and ovarian cancer .
1
1 Cited Publications
Cat. No.: HY-P73729
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCNA; Truncated Proliferating Cell Nuclear Antigen; Proliferating Cell Nuclear Antigen; DNA polymerase Delta Auxiliary Protein; DNA Sliding Clamp PCNA; ATLD2; Cyclin
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-163944
CAS No.: 3081311-94-3
Research Areas:
LL-K12-18 is a CDK12 kinase inhibitor and a dual-site molecular glue. LL-K12-18 inhibits human CDK12 with an IC50 value of 283.9 nM, and selectively degrades cyclin K via the ubiquitin-proteasome system by stabilizing the CDK12-DDB1 complex. LL-K12-18 downregulates DNA damage response genes, reduces the phosphorylation level of CTD Ser2 in RNA polymerase II, and modulates biomarkers such as ATM, RAD51, γ-H2AX and cleaved PARP, thereby effectively inducing apoptosis and inhibiting proliferation of breast cancer cells. LL-K12-18 exhibits high target selectivity and serves as a research tool for studies on triple-negative breast cancer .
Cat. No.: HY-125576
CAS No.: 26034-16-2
Cat. No.: HY-19587
CAS No.: 74517-42-3
Synonyms: NSC335153
Target:
Research Areas:
Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein .
Cat. No.: HY-143411
CAS No.: 2487526-28-1
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GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts .
Cat. No.: HY-100513
CAS No.: 34279-44-2
Category:
Target:
Cat. No.: HY-161916
CAS No.: 3043810-73-4
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Research Areas:
Polθ-IN-4 is an orally active prodrug of a DNA polymerase θ (Polθ) inhibitor with Kms of 3.7, 3.7 and 5.2 μM in human, mouse and rat recombinant alkaline phosphatases. Polθ-IN-4 that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 demonstrates significant anti-tumor activity in multiple animal experiments. Polθ-IN-4 can be used for the studies of breast cancer and ovarian cancer .
Cat. No.: HY-N9454
CAS No.: 91893-83-3
Cat. No.: HY-W150426
CAS No.: 135-65-9
Target:
Research Areas:
Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC50 of 12 μM. Naphthol AS-BS can be used for the research of infection .
Cat. No.: HY-N6733R
CAS No.: 38966-21-1
Category:
Synonyms: MKC-442
Target:
Research Areas:
Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .
Cat. No.: HY-19869
CAS No.: 878670-89-4
Target:
Research Areas:
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS .
Cat. No.: HY-E71047
Target:
Research Areas:
DNA Polymerase Alpha, Human (EC 2.7.7.7) is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2.
Cat. No.: HY-110139
CAS No.: 1489285-17-7
Target:
Research Areas:
Procaspase-IN-5 is a human DNA polymerase λ inhibitor. Procaspase-IN-5 has DNA polymerization function and TdT function with an IC50 value of 5.9 μM and 4.5 μM, respectively. Procaspase-IN-5 can be used for the research of cancer .
Cat. No.: HY-P7883
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: POLB; 5'-DRP Lyase; DNA polymerase Beta; AP Lyase; polymerase (DNA Directed), Beta; DNA polymerase Beta Subunit; 5'-Deoxyribose-Phosphate Lyase; DNA polymerase; polymerase (DNA) Beta; DNA Pol Beta
Species:
Human
Source:
E. coli
Cat. No.: HY-P703612
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: POLQ; DNA polymerase Eta; DNA polymerase Theta; PRO0327; POLH; polymerase (DNA Directed), Theta, Isoform CRA_c; polymerase (DNA Directed), Theta; Epididymis Secretory Sperm Binding Protein; polymerase (DNA) Theta
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P86846
Synonyms: DNA-directed DNA polymerase mu antibody; DNA-directed DNA/RNA polymerase mu antibody; DPOLM_human antibody; FLJ35482 antibody; Pol iota antibody; Pol Mu antibody; Polm antibody; POLM protein antibody; polymerase (DNA directed) mu antibody; polymerase DNA directed mu antibody; DNA-directed DNA polymerase mu antibody; DNA-directed DNA/RNA polymerase mu antibody; DPOLM_human antibody; FLJ35482 antibody; Pol iota antibody; Pol Mu antibody; Polm antibody; POLM protein antibody; polymerase (DNA directed) mu antibody; polymerase DNA directed mu antibody; Tdt N antibody; Tdt-N antibody; TdtN antibody; Terminal transferase antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
