26034-16-2
Chemical Structure
Griselimycin
- CAS No.: 26034-16-2
- Formula:C57H96N10O12
- Molecular Weight:1113.43
IUPAC Name: (2S,4R)-1-(N-acetyl-N-methyl-L-valyl)-N,4-dimethyl-N-((2R,6S,9S,10R,16R,18aS,24S,27S,29aS)-6,16,27-triisobutyl-24-isopropyl-2,10,17,25-tetramethyl-5,8,12,15,18,23,26,29-octaoxohexacosahydro-1H,12H-dipyrrolo[2,1-i:2',1'-r][1]oxa[4,7,10,13,16,19,22]heptaazacyclopentacosin-9-yl)pyrrolidine-2-carboxamide
InChIKey: JSNIAKPKPNJUEP-BHYOTPSJSA-N
SMILES: CC(N(C)[C@@H](C(C)C)C(N1[C@@H](C[C@H](C1)C)C(N([C@@H]2C(N[C@H](C(N3[C@](C[C@H](C3)C)([H])C(N[C@H](C(N([C@H](C(N4[C@](CCC4)([H])C(N([C@@H](C(NCC(O[C@@H]2C)=O)=O)CC(C)C)C)=O)=O)C(C)C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)C)=O)=O)=O
Biological Activity: Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria[1][2].
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Griselimycin | 98.2% | Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria. | ||||||||||||||||||||
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- [1]. Holzgrabe U, et al. New Griselimycins for Treatment of Tuberculosis. Chem Biol. 2015;22(8):981-982. [Content Brief]
- [2]. Fenwick MK, et al. Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens. Commun Biol. 2024;7(1):1622. Published 2024 Dec 5. [Content Brief]
Keywords
