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Results for "

human GITR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (1) TGF-beta/Smad (1) TNF Receptor (5)
By Research Areas:	Cancer (6) Inflammation/Immunology (2)
Oligonucleotides:	Antisense Oligonucleotides (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991180

TRX-518	TNF Receptor	Cancer
TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors^[1][2][3].

HY-159692

AZD8701 IONIS-1063734	TGF-beta/Smad	Inflammation/Immunology Cancer
AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC₅₀ of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .

HY-P991404

AMG-228	TNF Receptor	Cancer
AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting *TNFRSF18/GITR/CD357*. AMG-228 can be used in advanced solid tumors research .

HY-P991464

IBI37G5	TNF Receptor	Cancer
IBI37G5 is a human monoclonal antibody (mAb) targeting *TNFRSF18/GITR/CD357*. IBI37G5 has anti-tumor activity in MC38 and B16F10 mouse tumor models. IBI37G5 can be used in the study of cancer immunity .

HY-P992354

FPA154 INBRX-110	TNF Receptor NF-κB	Cancer
FPA154 is a human monoclonal antibody against *TNFRSF18/GITR/CD357. FPA154 activates NF-κB* via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992450

REGN6569	TNF Receptor	Cancer
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991180

TRX-518	TNF Receptor	Cancer
TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors^[1][2][3].

HY-P99876

Efaprinermin alfa OMP-336B11	Inhibitory Antibodies	Others
Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody targeting TNFRSF18. Efaprimermin alfa is a GITR ligand-Fc fusion protein .

HY-P991404

AMG-228	TNF Receptor	Cancer
AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting *TNFRSF18/GITR/CD357*. AMG-228 can be used in advanced solid tumors research .

HY-P991464

IBI37G5	TNF Receptor	Cancer
IBI37G5 is a human monoclonal antibody (mAb) targeting *TNFRSF18/GITR/CD357*. IBI37G5 has anti-tumor activity in MC38 and B16F10 mouse tumor models. IBI37G5 can be used in the study of cancer immunity .

HY-P990525

Anti-TNFRSF18/GITR/CD357 Antibody	Inhibitory Antibodies	Inflammation/Immunology
The Anti-TNFRSF18/GITR/CD357 Antibody is a CHO-expressed human antibody targeting *TNFRSF18/GITR/CD357. The Anti-TNFRSF18/GITR/CD357 Antibody features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TNFRSF18/GITR/CD357 Antibody can be referenced as Human* IgG1 kappa, Isotype Control (HY-P99001).

HY-P992354

FPA154 INBRX-110	TNF Receptor NF-κB	Cancer
FPA154 is a human monoclonal antibody against *TNFRSF18/GITR/CD357. FPA154 activates NF-κB* via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992450

REGN6569	TNF Receptor	Cancer
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .

Species:	Human (8)
Tag:	His (4) Avi (3) Flag (2) Fc (4)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78137

	GITR Protein, Human (Biotinylated, HEK293, His-Avi) CD357; GITR; GITR-D; TNFRSF18; AITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein with a C-terminal Avi label and a C-terminal His label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P73076

	GITR Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 18; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, His) is a recombinant protein with a C-terminal His label, It consists of 161 amino acids (M1-E161) and is produced in HEK293 cells.

HY-P75166

	GITR Protein, Human (Biotinylated, HEK293, Fc-Avi) Tumor necrosis factor receptor superfamily member 18; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (Biotinylated, HEK293, Fc-Avi) is a recombinant protein with a C-terminal Fc label and a C-terminal Avi label, It consists of 161 amino acids (M1-E161) and is produced in HEK293 cells.

HY-P70683

	GITR Protein, Human (HEK293, hFc) Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, hFc) is a recombinant protein with a C-terminal Fc label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P70822

	GITR Protein, Human (T45A, HEK293, mFc) Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
	GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (T45A, HEK293, mFc) is a recombinant protein with a C-terminal Fc label and T at position 45 is mutated to A. It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P78448

	AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) TNFSF18; AITRL; TL6; GITRL; GITR Ligand	Human	HEK293
	AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.

HY-P78791

	AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi) TNFSF18; AITRL; TL6; hGITRL; GITR Ligand	Human	HEK293
	AITRL/TNFSF18 protein binds to TNFRSF18/AITR/GITR and regulates T cell responses. AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived AITRL/TNFSF18 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 128 a.a., with molecular weight of 45-53 kDa.

HY-P78133

	AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag) TNFSF18; AITRL; TL6; GITRL; GITR Ligand	Human	HEK293
	AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, His-Flag) is a recombinant biotinylated human AITRL (Q72-S199) with N-terminal His and Flag tag, which is expressed in HEK293.

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HY-159692

AZD8701 IONIS-1063734		Antisense Oligonucleotides
AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC₅₀ of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .

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