17 Results for "

human GITR

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "human GITR" in MCE Product Catalog:

Cat. No.: HY-P991180

Target:  

TNF Receptor

Research Areas:  

Cancer

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].
loading...
    loading...
Cat. No.: HY-159692
CAS No.: 2603457-08-3
Synonyms: IONIS-1063734
Target:  

FOXP

Research Areas:  

Cancer

AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .
loading...
    loading...
Cat. No.: HY-P99876
CAS No.: 2102200-64-4
Synonyms: OMP-336B11

Target:  

Inhibitory Antibodies

Research Areas:  

Others

Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody targeting TNFRSF18. Efaprimermin alfa is a GITR ligand-Fc fusion protein .
loading...
    loading...
Cat. No.: HY-P991404

Target:  

TNF Receptor

Research Areas:  

Cancer

AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. AMG-228 can be used in advanced solid tumors research .
loading...
    loading...
Cat. No.: HY-P991464

Target:  

TNF Receptor

Research Areas:  

Cancer

IBI37G5 is a human monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. IBI37G5 has anti-tumor activity in MC38 and B16F10 mouse tumor models. IBI37G5 can be used in the study of cancer immunity .
loading...
    loading...
Cat. No.: HY-P992395
Synonyms: JNJ-711

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

JNJ-64164711 (JNJ-711) is a bifunctional antibody that simultaneously targets human GITR/TNFRSF18 and FcγRIIIa. JNJ-64164711 binds to the GITR domain to activate the NF-κB signaling pathway, while binding to FcγRIIIa to support antibody-dependent cellular cytotoxicity (ADCC). JNJ-64164711 can specifically eliminate GITR-positive hematological tumor cells, activated T cells and intratumoral regulatory T cells through the ADCC mechanism, thereby significantly enhancing the body's anti-tumor immune response. JNJ-64164711 can be used in research related to non-small cell lung cancer, colorectal cancer, prostate cancer, renal cell carcinoma and hematological tumors .
loading...
    loading...
Cat. No.: HY-P990525

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

The Anti-TNFRSF18/GITR/CD357 Antibody is a CHO-expressed human antibody targeting TNFRSF18/GITR/CD357. The Anti-TNFRSF18/GITR/CD357 Antibody features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TNFRSF18/GITR/CD357 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
loading...
    loading...
Cat. No.: HY-P992354
Synonyms: INBRX-110

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

FPA154 is a human monoclonal antibody against TNFRSF18/GITR/CD357. FPA154 activates NF-κB via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
loading...
    loading...
Cat. No.: HY-P78137
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD357; GITR; GITR-D; TNFRSF18; AITR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P992450

Target:  

TNF Receptor

Research Areas:  

Cancer

REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .
loading...
    loading...
Cat. No.: HY-P73076
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor superfamily member 18; CD357; TNFRSF18; AITR; GITR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P75166
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor superfamily member 18; CD357; TNFRSF18; AITR; GITR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P70683
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P70822
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78448
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFSF18; AITRL; TL6; GITRL; GITR Ligand
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78791
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF18; AITRL; TL6; hGITRL; GITR Ligand
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78133
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFSF18; AITRL; TL6; GITRL; GITR Ligand
Species:  
Source:  
loading...
    loading...
  • 1