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Results for "

human eosinophils

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

7

Inhibitory Antibodies

11

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P990774
    Verekitug

    ASP-7266; TRAB-1; UPB-101

    		 Interleukin Related Inflammation/Immunology
    Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .
    Verekitug
  • HY-19969
    YM-90709
    1 Publications Verification

    		 Interleukin Related Inflammation/Immunology
    YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [ 125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM .
    YM-90709
  • HY-W011696
    Oleylamine, 80-90%

    cis-1-Amino-9-octadecene, 80-90%

    		 Environmental Pollutants Biochemical Assay Reagents Cancer
    Oleylamine, 80-90% (cis-1-Amino-9-octadecene, 80-90%) is a multifunctional reagent used for metal ion coordination and nanoparticle surface modification, and acts as a solvent, surfactant and reducing agent in the synthesis of metal oxide nanoparticles. Oleylamine, 80-90% regulates nanoparticle morphology, magnetization intensity and water proton relaxation rate via thiol-ene "click" reaction, and enhances the colloidal stability of nanoparticles in organic reagents. Oleylamine, 80-90% is mainly used in research and applications in fields such as nanomaterial synthesis, biomedical imaging (MRI contrast agents, fluorescent probes), cancer cell targeting and drug delivery .
    Oleylamine, 80-90%
  • HY-P99371
    Lirentelimab

    AK002; Antolimab

    		 Apoptosis Inflammation/Immunology
    Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .
    Lirentelimab
  • HY-15342
    Timapiprant
    4 Publications Verification

    OC000459

    		 Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
    Timapiprant
  • HY-123205
    Oxatomide

    KW-4354

    		 Histamine Receptor P2X Receptor 5-HT Receptor Apoptosis PERK p38 MAPK COX Inflammation/Immunology
    Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases .
    Oxatomide
  • HY-P990213
    Anti-Mouse/Human IL-5 Antibody (TRFK5)

    		Interleukin Related Inflammation/Immunology
    Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse IL-5 IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma .
    Anti-Mouse/Human IL-5 Antibody (TRFK5)
  • HY-15342A
    Timapiprant sodium
    4 Publications Verification

    OC000459 sodium

    		 Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
    Timapiprant sodium
  • HY-101188
    INCB38579

    		Histamine Receptor Infection
    INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities .
    INCB38579
  • HY-17457
    Levalbuterol hemitartrate

    Levosalbutamol hemitartrate

    		 Adrenergic Receptor PI3K Inflammation/Immunology
    Levalbuterol (Levosalbutamol) hemitartrate is a β2-adrenergic receptor agonist and PI3K inhibitor. Levalbuterol hemitartrate inhibits PI3K activity, reduces NF-κB and Rb protein expression, activates the cAMP/PKA pathway, and stimulates cAMP release. Levalbuterol hemitartrate relaxes airway smooth muscle, reduces intracellular calcium levels, and inhibits spasmogen-induced contractions. Levalbuterol hemitartrate can be used for the research of moderate-to-severe asthma .
    Levalbuterol hemitartrate
  • HY-P99846
    Dectrekumab

    QAX576

    		 Interleukin Related Inflammation/Immunology
    Dectrekumab (QAX576) is a human monoclonal antibody that targets IL-13. Dectrekumab significantly improves intraepithelial esophageal eosinophil counts and dysregulated esophageal disease-related transcripts with Eosinophilic esophagitis (EoE) in a sustained manner and can be used for inflammation and immunology related research .
    Dectrekumab
  • HY-122558
    AM432 sodium

    		Prostaglandin Receptor Neurological Disease
    AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease .
    AM432 sodium
  • HY-177304
    Anti-inflammatory agent 104

    		TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 104 (Compound 26) is an anti-inflammatory compound. The IC50 of Anti-inflammatory agent 104 for the inhibition of TNF-α synthesis and release in the human macrophage cell line U937 is 0.024 nM. Anti-inflammatory agent 104 can reduce eosinophils in rat lungs by 63% .
    Anti-inflammatory agent 104
  • HY-137308
    15(R)-Prostaglandin D2

    15R-PGD2

    		 Prostaglandin Receptor Inflammation/Immunology
    15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets .
    15(R)-Prostaglandin D2
  • HY-P991599
    SHR-1703

    		Interleukin Related Inflammation/Immunology
    SHR-1703 is a long-acting humanized anti-IL-5 IgG1 monoclonal antibody. SHR-1703 can selectively recognize and bind to IL-5, blocking the binding of IL-5 to the α chain of the receptor on the surface of eosinophils, thereby inhibiting the proliferation, activation, and migration of eosinophils, and ultimately reducing eosinophil-mediated inflammation and damage. SHR-1703 can be used in the research of eosinophil-related diseases, such as eosinophilic asthma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
    SHR-1703
  • HY-174763
    Human CCL2 mRNA

    		mRNA Inflammation/Immunology
    Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.
    Human CCL2 mRNA
  • HY-174639
    Human IL13 mRNA

    		mRNA Inflammation/Immunology
    Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
    Human IL13 mRNA
  • HY-174770
    Human CCL13 mRNA

    		mRNA Inflammation/Immunology
    Human CCL13 mRNA encodes the human C-C motif chemokine ligand 13 (CCL13) protein, a cytokine that displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. CCL13 also plays a role in accumulation of leukocytes during inflammation and may be involved in the recruitment of monocytes into the arterial wall during artherosclerosis.
    Human CCL13 mRNA
  • HY-174754
    Human CCL28 mRNA

    		mRNA Inflammation/Immunology
    Human CCL28 mRNA encodes the human C-C motif chemokine ligand 28 (CCL28) protein, a cytokine that displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. CCL28 may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.
    Human CCL28 mRNA
  • HY-174607
    Human IL33 mRNA

    		mRNA Inflammation/Immunology
    Human IL33 mRNA encodes the human interleukin 33 (IL33) protein, a cytokine that binds to the IL1RL1/ST2 receptor. IL33 is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells.
    Human IL33 mRNA
  • HY-174756
    Human CCL26 mRNA

    		mRNA Inflammation/Immunology
    Human CCL26 mRNA encodes the human C-C motif chemokine ligand 26 (CCL26) protein, a cytokine that displays chemotactic activity for normal peripheral blood eosinophils and basophils. CCL26 also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.
    Human CCL26 mRNA
  • HY-174760
    Human CCL22 mRNA

    		mRNA Inflammation/Immunology
    Human CCL22 mRNA encodes the human C-C motif chemokine ligand 22 (CCL22) protein, a cytokine that displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. CCL22 also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes.
    Human CCL22 mRNA
  • HY-12284
    NVP-QAV680

    		Prostaglandin Receptor Inflammation/Immunology
    NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with low nanomolar (nM) functional potency to inhibit CRTh2-driven activation of human eosinophils and Th2 lymphocytes. NVP-QAV680 exhibits good oral bioavailability and demonstrates efficacy in CRTh2-dependent mechanisms and allergic disease models in rats .
    NVP-QAV680
  • HY-N7801
    (±)5-HEPE

    		Drug Isomer Metabolic Disease
    (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
    (±)5-HEPE
  • HY-137863
    Pemirolast

    		Histamine Receptor Cardiovascular Disease Inflammation/Immunology
    Pemirolast is an orally active antiallergic agent. Pemirolast attenuates Paclitaxel (HY-B0015) hypersensitivity reactions. Pemirolast can be used for bronchial asthma and conjunctivitis research - .
    Pemirolast
  • HY-174602
    Human IL5 mRNA

    		mRNA Inflammation/Immunology
    Human IL5 mRNA encodes the human interleukin 5 (IL5) protein, a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5 plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases.
    Human IL5 mRNA
  • HY-E70992
    Eosinophil Peroxidase, Human

    		Endogenous Metabolite Metabolic Disease
    Eosinophil Peroxidase, Human (EC 1.11.1.7) is an enzyme found in eosinophils (innate immune cells of humans and mammals). Eosinophil Peroxidase, Human (EC 1.11.1.7) is a heme peroxidase whose activities include oxidizing halide ions to reactive oxygen species with bactericidal effects, disrupting bacterial cell walls with cations, and performing post-translational modifications on protein amino acid residues.
    Eosinophil Peroxidase, Human
  • HY-174749
    Human CCL8 mRNA

    		mRNA Inflammation/Immunology
    Human CCL8 mRNA encodes the human C-C motif chemokine ligand 8 (CCL8) protein, a member of the CC subfamily. CCL8 displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils.
    Human CCL8 mRNA
  • HY-174745
    Human CCR3 mRNA

    		mRNA Inflammation/Immunology
    Human CCR3 mRNA encodes the human C-C motif chemokine receptor 3 (CCR3) protein, a member of G protein-coupled receptors family. CCR3 may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
    Human CCR3 mRNA
  • HY-131827
    5-Chlorouridine

    		DNA/RNA Synthesis Inflammation/Immunology
    5-Chlorouridine, a ribonucleoside, is an inhibitor of RNase A (Ki = 44.5 μM) and eosinophil derived neurotoxin (EDN) (Ki = 1080.1 μM; IC50 = 1462.8 μM). 5-Chlorouridine can be used for the researches of inflammatory disorders and hypereosinophilic syndromes .
    5-Chlorouridine
  • HY-174751
    Human CCL5 mRNA

    		mRNA Inflammation/Immunology
    Human CCL5 mRNA encodes the human C-C motif chemokine ligand 5 (CCL5) protein, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. CCL5 is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
    Human CCL5 mRNA
  • HY-P992447
    QX008N

    		Interleukin Related Inflammation/Immunology
    QX008N is a humanized IgG1 monoclonal antibody and also a TSLP inhibitor with a KD value of 0.0175 nM. QX008N blocks TSLP-induced signaling pathways by inhibiting the interaction of TSLP-TSLPR-IL-7Rα. QX008N reduces eosinophil and IgE levels, improves pulmonary function, blocks TSLP-induced inflammation, and enhances the inhibitory effect on inflammatory mediators when administered in combination with anti-IL-4R antibodies. QX008N is applicable to relevant research on asthma .
    QX008N
  • HY-P992440
    PF-06817024

    		Interleukin Related Inflammation/Immunology
    PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases .
    PF-06817024
  • HY-182736
    YM-344484

    		CCR Histamine Receptor Calcium Channel Inflammation/Immunology
    YM-344484 is an orally active dual antagonist of chemokine CCR3 receptor and histamine histamine H1 receptor. YM-344484 inhibits ligand-induced Ca 2+ influx, chemotaxis of CCR3-expressing cells, histamine-induced Ca 2+ influx, increased vascular permeability and eosinophil accumulation. YM-344484 suppresses vascular permeability and inhibits eosinophil infiltration in a mouse asthma model. YM-344484 can be used in research related to asthma, allergic rhinitis and atopic dermatitis .
    YM-344484
  • HY-182637
    ACT-774312

    		Prostaglandin Receptor Inflammation/Immunology
    ACT-774312 is a potent and selective CRTH2 antagonist with an IC50 of 4 nM. ACT-774312 blocks the activity and internalization of the CRTH2 receptor, and inhibits PGD2-induced morphological changes in eosinophils. ACT-774312 can be used in the research of nasal polyps and type 2 inflammatory diseases.
    ACT-774312

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