AM432 sodium
AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease.
For research use only. We do not sell to patients.
- CAS No.: 1263409-34-2
- Formula: C29H31N2NaO5
- Molecular Weight:510.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
31 nM
Compound: 21, AM432
|
Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation counting in presence of 0.2 % HSA
Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation counting in presence of 0.2 % HSA
|
[PMID: 21211969] |
| HEK293 | IC50 |
6 nM
Compound: 21, AM432
|
Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation counting
Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation counting
|
[PMID: 21211969] |
Chemical Information
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CAS No. 1263409-34-2
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Molecular Weight 510.56
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Formula C29H31N2NaO5
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SMILES
O=C(O[Na])CC1=CC(C2=CC=C(C3=CC=C(OCC)N=C3)C=C2CN(C(C4CC4)=O)CC)=C(OC)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)