1246207-65-7
1246207-65-7
Chemical Structure
INCB38579
- CAS No.: 1246207-65-7
- Formula:C25H34N6O
- Molecular Weight:434.58
IUPAC Name: 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-cyclopentylethan-1-one
InChIKey: LZOCXAJJOQPLKB-UHFFFAOYSA-N
SMILES: O=C(CC1CCCC1)N2CCC3=CC=C(C4=NC(N)=NC(N5CCN(C)CC5)=C4)C=C3C2
Biological Activity: INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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INCB38579 | 99.33% | INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.65
HY-145106Histamine H4 receptor antagonist-1 -
Similarity Score 0.55
HY-101420RVUF10460 (Standard) -
Similarity Score 0.51
HY-153464CXCR4-IN-1 -
Similarity Score 0.49
HY-120541ST-1006 -
Similarity Score 0.48
HY-1553165-HT6R antagonist 2 -
Similarity Score 0.48
HY-146401CXCR4 antagonist 6 -
Similarity Score 0.48
HY-146372CXCR4 antagonist 5 -
Similarity Score 0.48
HY-165453VUF14480 -
Similarity Score 0.48
HY-118052BPKDi -
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