1246207-65-7
1246207-65-7
Chemical Structure
INCB38579
- CAS No.: 1246207-65-7
- Formula:C25H34N6O
- Molecular Weight:434.58
IUPAC Name: 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-cyclopentylethan-1-one
InChIKey: LZOCXAJJOQPLKB-UHFFFAOYSA-N
SMILES: O=C(CC1CCCC1)N2CCC3=CC=C(C4=NC(N)=NC(N5CCN(C)CC5)=C4)C=C3C2
Biological Activity: INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
INCB38579 | 99.33% | INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
