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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
human lactate dehydrogenase A
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "human lactate dehydrogenase A" in MCE Product Catalog:
9
9 Cited Publications
Research Areas:
GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer .
3
3 Cited Publications
Target:
Research Areas:
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
Cat. No.: HY-147342
CAS No.: 156724-91-3
Target:
Research Areas:
β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a Ki value of 90 μM, and inhibits human IMPDH with IC50 values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .
Cat. No.: HY-154865
CAS No.: 2924532-47-6
Target:
Research Areas:
Anticancer agent 121, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .
Cat. No.: HY-154866
CAS No.: 2924532-50-1
Target:
Research Areas:
Anticancer agent 122, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research .
Target:
Research Areas:
Lactate Dehydrogenase, Human (E. coli) is a recombinant human lactate dehydrogenase (LDH) protein—a redox enzyme that catalyzes the reversible interconversion between lactate and pyruvate. Lactate Dehydrogenase, Human (E. coli) is primarily utilized in life science research, the diagnosis of tissue injury, and as an enzymatic marker.
Cat. No.: HY-P70225
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LDHA; Epididymis Secretory Sperm Binding Protein Li 133P; lactate dehydrogenase A; Proliferation-Inducing Gene 19; L-lactate dehydrogenase A Chain; lactate dehydrogenase M; LDH Muscle Subunit; L-lactate dehydrogenase; Cell Proliferation-Inducing Gene 19 P
Species:
Human
Source:
E. coli
Cat. No.: HY-N20238
Synonyms: Gallnut extract
Category:
Target:
Cat. No.: HY-111108R
CAS No.: 1964515-43-2
Research Areas:
LDH-IN-1 (Standard) is the analytical standard of LDH-IN-1 (HY-111108). This product is intended for research and analytical applications. LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
Cat. No.: HY-100742R
CAS No.: 1802977-61-2
GNE-140 racemate (Standard) is the analytical standard of GNE-140 racemate (HY-100742). This product is intended for research and analytical applications. GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
