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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
iNOs-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "iNOs-IN-1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-145846
Purity: 99.54%
Target:
Research Areas:
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects [1].
2
2 Cited Publications
Target:
Research Areas:
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .
Category:
Myristicaceae Plants Endogenous metabolite Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Terpenoids Myristica fragrans Houtt. Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N0506
CAS No.: 84954-93-8
Target:
Category:
Target:
Research Areas:
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis [1].
Cat. No.: HY-N8559
CAS No.: 40738-40-7
Cat. No.: HY-100986B
CAS No.: 36889-13-1
Target:
Research Areas:
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .
Cat. No.: HY-146066A
Purity: 98.45%
Target:
Research Areas:
(R)-α7 nAchR-JAK2-STAT3 agonist 1 is the R-enantiomer of α7 nAchR-JAK2-STAT3 agonist 1 (HY-146066). α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis [1].
Cat. No.: HY-108054
CAS No.: 364067-22-1
Synonyms: SD-6010
Target:
Research Areas:
Cindunistat (SD-6010) is a potent, orally active and selective iNOS inhibitor .
Cat. No.: HY-172451
Target:
NADPH Oxidase Monoamine Oxidase Reactive Oxygen Species (ROS) NO Synthase Interleukin Related
Research Areas:
MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6 [1].
Cat. No.: HY-N0506R
CAS No.: 84954-93-8
Category:
Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Terpenoids Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite
Target:
Cat. No.: HY-N15305
CAS No.: 39380-12-6
Target:
Cat. No.: HY-184692
Research Areas:
NF-κB/STAT3/iNOS-IN-1 is a NF-κB/STAT3/iNOS inhibitor. NF-κB/STAT3/iNOS-IN-1 reduces the expression of inflammatory mediators TNF-α, IL-1β, IL-6, IL-8 and COX-2. NF-κB/STAT3/iNOS-IN-1 upregulates the expression of epithelial barrier-related proteins E-cadherin, Occludin and Zonula occludens-1. NF-κB/STAT3/iNOS-IN-1 alleviates disease severity and histopathological damage in mouse colitis models. NF-κB/STAT3/iNOS-IN-1 can be used for the research of inflammatory bowel disease (colitis) [1].
Cat. No.: HY-171251
CAS No.: 1113116-62-3
Target:
Research Areas:
RGS10 modulator-1 (compound 15) is a potent RGS10 modulator. RGS10 modulator-1 significantly reverses IFNγ-induced RGS10 protein and mRNA expression. RGS10 modulator-1 reverse the IFNγ-induced COX-2 mRNA and iNOS expression .
Cat. No.: HY-N9086A
CAS No.: 70460-58-1
Synonyms: 5,7,4'-Trihydroxy-6-methylflavanone
Cat. No.: HY-108054A
CAS No.: 753491-31-5
Synonyms: SD-6010 hydrochloride maleate
Target:
Research Areas:
Cindunistat hydrochloride maleate is a potent, orally active and selective iNOS inhibitor .
Cat. No.: HY-180938
CAS No.: 3107638-80-9
Target:
Research Areas:
Fyn-IN-1 (Compound 43) is a selective, blood-brain barrier permeable Fyn and GSK-3β inhibitor with IC50 values of 0.044 μM and 0.61 μM, respectively. Fyn-IN-1 significantly downregulates the pro-inflammatory enzyme iNOS. Fyn-IN-1 can be used in the research of neurodegenerative diseases [1].
Cat. No.: HY-179646
CAS No.: 3122563-80-5
Research Areas:
CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC50 of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides (HY-D1056) (LPS)-induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6). CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
