2108714-20-9
Chemical Structure
α7 nAchR-JAK2-STAT3 agonist 1
- CAS No.: 2108714-20-9
- Formula:C25H30O6
- Molecular Weight:426.50
IUPAC Name: (S)-4-(3-acetoxy-7-phenylheptyl)-1,2-phenylene diacetate
InChIKey: ONTKJJHFOWPHNJ-QHCPKHFHSA-N
SMILES: O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C
Biological Activity: α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].
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α7 nAchR-JAK2-STAT3 agonist 1 | 98.51% | α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis. | ||||||||||||||||||||
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Keywords
