2. Membrane Transporter/Ion Channel Neuronal Signaling JAK/STAT Signaling Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. nAChR JAK STAT NO Synthase
  4. α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.

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α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure

α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure

CAS No. : 2108714-20-9

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α7 nAchR-JAK2-STAT3 agonist 1 Related Antibodies

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Description

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].

IC50 & Target

IC50: 0.32 μM (NO)[1]
Molecular Weight

426.50

Formula

C25H30O6
CAS No.
SMILES

O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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α7 nAchR-JAK2-STAT3 agonist 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α7 nAchR-JAK2-STAT3 agonist 12108714-20-9nAChRJAKSTATNO SynthaseNicotinic acetylcholine receptorsJanus kinaseNitric oxide synthasesNOSSepsisRAW264.7LPS-inducedCytokineInhibitorinhibitorinhibit

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