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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
intestinal mucosal barrier
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "intestinal mucosal barrier" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W145499
CAS No.: 4468-02-4
Target:
Research Areas:
Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD50 of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements .
1
1 Cited Publications
Cat. No.: HY-N2376
CAS No.: 35775-49-6
Category:
Flavones Plants Oroxylum indicum (Linn.) Bentham ex Kurz Flavonoids Monophenols Labiatae Other Diseases Phenols Bignoniaceae Disease Research Fields Medicago truncatula Gaertn.
Target:
Cat. No.: HY-N2128
CAS No.: 18110-86-6
Category:
Alkaloids Simaroubaceae Plants Disease Research Fields Inflammation/Immunology Picrasma quassioides(D．Don)Benn． Indole Alkaloids
Target:
Cat. No.: HY-N0688
CAS No.: 13476-25-0
Cat. No.: HY-170522
CAS No.: 2924181-80-4
Synonyms: ISM012-042
Target:
Research Areas:
Garutadustat (ISM012-042) is an orally active, selective inhibitor of PHD1 and PHD2, with IC50 values of 1.9 nM and 2.5 nM, respectively. Garutadustat stabilizes HIF1α protein in intestinal epithelial cells, thereby activating gene transcription programs associated with mucus production, tight junction formation, anti-inflammatory mediator generation and wound healing, which fundamentally promotes mucosal barrier repair and regulates intestinal immunity. Garutadustat can be used for the research of inflammatory bowel disease .
Cat. No.: HY-P2958
CAS No.: 37289-07-9
Synonyms: Bile salt hydrolase
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Research Areas:
Choloylglycine hydrolase (Bile salt hydrolase) is an important intestinal hydrolase. Choloylglycine hydrolase not only catalyzes the decomposition of conjugated bile acids into free bile acids and amino acids, but also exhibits amine N-acyltransferase activity, which re-links amino acids/amines to free bile acids (even conjugated bile acids) to produce bacterial bile acid amides. Choloylglycine hydrolase regulates the composition of the bile acid pool, intestinal mucosal barrier integrity, intestinal inflammatory responses, intestinal flora composition, host weight gain, circadian rhythm, and colonization resistance to Clostridioides difficile. Choloylglycine hydrolase can be used in the research of inflammatory bowel diseases, including ulcerative colitis and Crohn's disease .
Cat. No.: HY-161343
CAS No.: 2373280-36-3
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Research Areas:
HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function .
Cat. No.: HY-P11423
Target:
Research Areas:
Cat. No.: HY-N2376R
CAS No.: 35775-49-6
Category:
Flavonoids Monophenols Flavones Labiatae Phenols Plants Bignoniaceae Oroxylum indicum (Linn.) Bentham ex Kurz Medicago truncatula Gaertn.
Target:
Cat. No.: HY-N0688R
CAS No.: 13476-25-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
