lipoprotein lipase

By Targets:	ATGL (1) Lipase (4) Apoptosis (3) Biochemical Assay Reagents (1) Carboxylesterase (CES) (1) Endogenous Metabolite (6) Environmental Pollutants (1) Ferroptosis (1) Free Fatty Acid Receptor (1) Glycosidase (1) LPL Receptor (1) Mitochondrial Metabolism (1) NF-κB (1) PPAR (1) Reactive Oxygen Species (ROS) (1) Stearoyl-CoA Desaturase (SCD) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Inflammation/Immunology (3) Metabolic Disease (9)
Oligonucleotides:	Emulsifiers (1) Solubilizing Agents (1)

Targets Recommended: Lipase DAGL LDLR MAGL Hormone-Sensitive Lipase (HSL) ATGL LOX-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1005

Poloxamer 407 (F127) 5+ Cited Publications PEG-PPG-PEG, 12600 (Average Mn)	Environmental Pollutants LPL Receptor	Inflammation/Immunology
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a **lipoprotein lipase** inhibitor .

HY-N7072

Grape seed extract 2 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-P10735

GIP (mouse) Gastric inhibitory polypeptide(mouse); GIP(1-42) (mouse)	Lipase Apoptosis	Metabolic Disease
GIP (Gastric inhibitory polypeptide) (mouse) is a gastrointestinal hormone that is secreted by the intestinal K cells, and also expressed in and secreted from pancreatic islets. GIP (mouse) promotes insulin secretion from pancreatic β cells via the G-protein-coupled GIP receptor (GIPR). GIP (mouse) promotes pancreatic β cell proliferation and inhibits apoptosis. GIP (mouse) also exerts direct lipogenic effects on adipose tissue .

HY-P2752

Lipoprotein lipase, Pseudomonas sp LPL	Endogenous Metabolite	Metabolic Disease Cancer
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

HY-110390

GR148672X	Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis	Cardiovascular Disease Cancer
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .

HY-117549

Ibrolipim NO-1886	Lipase	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects .

HY-116538

(10E,12Z)-Octadeca-10,12-dienoic acid 1 Publications Verification trans-10,cis-12 CLA2	Endogenous Metabolite PPAR NF-κB Stearoyl-CoA Desaturase (SCD) Lipase	Metabolic Disease Inflammation/Immunology Cancer
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice .

HY-119741

Salacinol	Glycosidase Lipase	Metabolic Disease
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and **lipoprotein lipase**. Salacinol can be used for the research of diabetes mellitus .

HY-P991574

MEDI-5884 REG-101	ATGL	Cardiovascular Disease
MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting *Endothelial lipase* (EL)*. MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins* (HDL). MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research .

HY-P2733C

Glycerol-3-phosphate oxidase, microorganism GPO, microorganism	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate oxidase, microorganism is an enzyme that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate, producing hydrogen peroxide in the process. Glycerol-3-phosphate oxidase is located in the mitochondria of microorganisms and is involved in the glycerol-3-phosphate cycle, regulating cellular energy metabolism. Glycerol-3-phosphate oxidase, microorganism can be used in conjunction with Lipoprotein Lipase and Glycerol Kinase to determine triglyceride levels .

HY-P2752A

Lipoprotein Lipase, Bovine	Endogenous Metabolite	Metabolic Disease
Lipoprotein lipase, Bovine (EC 3.1.1.34) belongs to the lipase gene family and is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins (such as those in chylomicrons and very low-density lipoproteins (VLDL)) into two free fatty acid molecules and one monoacylglycerol molecule. Lipoprotein also participates in promoting cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. Lipoprotein requires ApoC-II as a cofactor. Lipoprotein attaches to the luminal surface of capillary endothelial cells via glycosylphosphatidylinositol high-density lipoprotein-binding protein 1 (GPIHBP1) and heparan sulfate proteoglycan.

HY-P2752B

Lipoprotein Lipase, Burkholderia sp.	Endogenous Metabolite	Metabolic Disease
Lipoprotein Lipase, Burkholderia sp. (EC 3.1.1.34) belongs to the lipase gene family and is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins (such as those in chylomicrons and very low-density lipoproteins (VLDL)) into two free fatty acid molecules and one monoacylglycerol molecule. Lipoprotein also participates in promoting cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. Lipoprotein requires ApoC-II as a cofactor. Lipoprotein attaches to the luminal surface of capillary endothelial cells via glycosylphosphatidylinositol high-density lipoprotein-binding protein 1 (GPIHBP1) and heparan sulfate proteoglycan.

HY-P2752C

Chemically modified Pseudomonas species Lipoprotein Lipase	Biochemical Assay Reagents	Others
Chemically modified Pseudomonas species Lipoprotein Lipase hydrolyzes triglycerides into three free fatty acids and glycerol.

HY-130064

Omega-3 acid ethyl esters P-OM3	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Omega-3 acid ethyl esters (P-OM3) is a omega-3 polyunsaturated fatty acid. Omega-3 acid ethyl esters can be used for the researches of severe hypertriglyceridemia and cardiovascular diseases .

Cat. No.	Product Name	Type

HY-D1005

Poloxamer 407 (F127) 5+ Cited Publications PEG-PPG-PEG, 12600 (Average Mn)	Biochemical Assay Reagents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a **lipoprotein lipase** inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P10735

GIP (mouse) Gastric inhibitory polypeptide(mouse); GIP(1-42) (mouse)	Lipase Apoptosis	Metabolic Disease
GIP (Gastric inhibitory polypeptide) (mouse) is a gastrointestinal hormone that is secreted by the intestinal K cells, and also expressed in and secreted from pancreatic islets. GIP (mouse) promotes insulin secretion from pancreatic β cells via the G-protein-coupled GIP receptor (GIPR). GIP (mouse) promotes pancreatic β cell proliferation and inhibits apoptosis. GIP (mouse) also exerts direct lipogenic effects on adipose tissue .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991574

MEDI-5884 REG-101	ATGL	Cardiovascular Disease
MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting *Endothelial lipase* (EL)*. MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins* (HDL). MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7072

Grape seed extract 2 Publications Verification	Natural Products Classification of Application Fields Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology Source Classification	Apoptosis
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-119741

Salacinol	Structural Classification Natural Products Salacia reticulata Wight Celastraceae Plants Source Classification	Glycosidase Lipase
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and **lipoprotein lipase**. Salacinol can be used for the research of diabetes mellitus .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2) IF-Tissue (1) IHC-F (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85262

	Lipoprotein Lipase Antibody (YA4954) LPL; LIPD; lipoprotein lipase; LPL	WB, IHC-P, IHC-F, IF-Tissue	Human
	Lipoprotein Lipase Antibody (YA4954) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Lipoprotein Lipase.

HY-P81831

	Lipoprotein Lipase Antibody (YA1576) LPL; LIPD; lipoprotein lipase; LPL	WB, IHC-P	Human
	Lipoprotein Lipase Antibody (YA1576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lipoprotein Lipase.

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HY-D1005

Poloxamer 407 (F127) 5+ Cited Publications PEG-PPG-PEG, 12600 (Average Mn)		Emulsifiers Solubilizing Agents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a **lipoprotein lipase** inhibitor .

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lipoprotein lipase

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