2 Results for "

mTNBC

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "mTNBC" in MCE Product Catalog:

Cat. No.: HY-P99682
CAS No.: 1629760-28-6
Synonyms: hLIV22

Target:  

ADC Antibodies

Research Areas:  

Cancer

Ladiratuzumab (hLIV22) is a humanized monoclonal antibody against zinc transporter LIV-1/ZIP6. Ladiratuzumab is conjugated to MMAE (HY-15162) via a cleavable dipeptide linker to synthesize an antibody-drug conjugate (ADC) Ladiratuzumab vedotin (HY-P99683). Ladiratuzumab vedotin selectively targets LIV-1 protein overexpressed on the surface of tumor cells, enters cells through antibody-mediated receptor endocytosis, releases MMAE to inhibit microtubule polymerization, and kills adjacent tumor cells with a bystander effect. Ladiratuzumab can be used in the study of solid tumors such as metastatic triple-negative breast cancer (mTNBC) .
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Cat. No.: HY-148923
CAS No.: 3034176-57-0
Purity:  98.34%
Target:  

STAT

Research Areas:  

Cancer

MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC) .
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